Focal point technology: Controlling treatment depth and pattern of skin injury by a novel highly focused laser

作者：Dieter Manstein, Henry H. Chan, Jayant D. Bhawalkar, Irina Erenburg, Hyemin Pomerantz, Jhony Escobar, Zeina Tannous, Jane Yoo, Thanh-Nga Tran, Raj Katkam, R. R. Anderson · 发表于：Journal of the American Academy of Dermatology · 年份：2024 · DOI：10.1016/j.jaad.2024.09.004 · 被引用次数：6 · 研究领域：Dermatologic Treatments and Research、Laser Applications in Dentistry and Medicine、Laser Material Processing Techniques

BACKGROUND: Selective photothermolysis has limitations in efficacy and safety for dermal targets. We describe a novel concept using scanned focused laser microbeams for precise control of dermal depth and pattern of injury, using a 1550 nm laser that generates an array of conical thermal zones while minimizing injury to the epidermis. OBJECTIVE: To characterize the conical thermal zones in vivo and determine safe starting parameters to transition to a second phase to explore potential clinical indications. METHODS: A focused toroidal (ring) laser beam was delivered through a cold sapphire window, sparing epidermal injury in a central zone. Pulse energy, lesion depth, density, and energy delivery were titrated in ex vivo human skin and subsequently on the backs of 21 human subjects. RESULTS: Histology showed microscale patterns of thermal injury, which varied predictably with laser parameters. Time-course healing through histology and skin surface imaging demonstrated the ability of the device to deliver high energies without sequelae. LIMITATIONS: Clinical data are currently being collected to further explore the safety and efficacy of the device. CONCLUSION: The 1550 nm laser with focal point technology enables precise control of lesion depth while simultaneously sparing a large portion of the epidermis, lowering the risk of adverse effects.