Correlation Between Coronary Calcification and Cardiac Structure in Non-Dialysis Patients with Chronic Kidney Disease

作者：Siyi Rao, Mengjie Weng, Ruoshan Lian, Yongjie Zhuo, Jiaqun Lin, Danyu You, Jiong Cui, Yi Chen, Jianxin Wan · 发表于：ESC Heart Failure · 年份：2024 · DOI：10.1002/ehf2.15057 · 被引用次数：7 · 研究领域：Cardiovascular Function and Risk Factors、Cardiac Imaging and Diagnostics、Parathyroid Disorders and Treatments

AIMS: We aim to explore the correlation between coronary artery calcification (CAC) score (CACS) and cardiac structure and function in chronic kidney disease (CKD) patients, create a clinical prediction model for severe CAC associated with cardiac ultrasound indexes. METHODS AND RESULTS: The study included 178 non-dialysis CKD patients who underwent CACS testing and collected general information, serological indices, cardiac ultrasound findings and follow-up on renal function, heart failure (HF) manifestations and re-hospitalization. The mean age of participants in the study cohort was 67.4 years; 59% were male, and 66.9% of patients had varying degrees of comorbid CAC. CKD patients with CACS > 100 were older, predominantly male and had a higher proportion of smoking, diabetes and hypertension (P < 0.05) compared with those with CACS = 0 and 0 < CACS ≤ 100, and had higher brain natriuretic peptide, serum magnesium and fibrinogen levels were also higher (P < 0.05). CACS was positively correlated with left atrial inner diameter (LAD), left ventricular end-diastolic inner diameter (LVDd), left ventricular volume at diastole (LVVd), output per beat (SV) and mitral orifice early diastolic blood flow velocity/early mitral annular diastolic myocardial motion velocity (E/e) (P < 0.05). We tested the associations between varying degrees of CAC and HF and heart valve calcification using multivariable-adjusted regression models. The risk of HF in patients with severe CAC was about 1.95 ...