Anticancer potential of active alkaloids and synthetic analogs derived from marine invertebrates

作者：Chunyan Cai, Dejun Yang, Yi Cao, Zhaolei Peng, Yulin Wang, Jingjing Xi, Chunmei Yan, Xiaofang Li · 发表于：European Journal of Medicinal Chemistry · 年份：2024 · DOI：10.1016/j.ejmech.2024.116850 · 被引用次数：15 · 研究领域：Marine Sponges and Natural Products、Synthesis and Biological Activity、Microbial Natural Products and Biosynthesis

In recent years, the number of cancers has soared, becoming one of the leading causes of human death. At the same time, marine anticancer substances have been the focus of marine drug research. Marine alkaloids derived from marine invertebrates like sponges are an important class of secondary metabolites, which have good bioactivities of blocking the cancer cell cycle, inducing autophagy and apoptosis of cancer cells, inhibiting cancer cell invasion and proliferation. They show potential as anticancer drug candidates. Therefore, in this review, we focus on the detailed introduction of bioactive alkaloids and their synthetic analogs from marine invertebrates, such as 4-chloro fascapysin and other 41 kinds of marine alkaloids or marine alkaloid synthetic analogs. They have significant anticancer activities on breast cancer, cervical cancer, colorectal cancer, prostate cancer, lung cancer, liver cancer, and so on. It provides new candidate compounds for anticancer drug research and provides a reference basis for marine drug resources research.