Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study

作者：Enmin Ding, Fuchang Deng, Jianlong Fang, Juan Liu, Wenyan Yan, Qiao Yao, Ke Miao, Yu Wang, Peijie Sun, Chenfeng Li, Yuanyuan Liu, Haoran Dong, Dong Li, Xu Zhang, Yifu Lu, Lin Xiao, Changming Ding, Tiantian Li, Yali Shi, Yaqi Cai, Xiaohui Liu, Krystal J. Godri Pollitt, John S. Ji, Shilu Tong, Song Tang, Xiaoming Shi · 发表于：Environmental Health Perspectives · 年份：2024 · DOI：10.1289/ehp13864 · 被引用次数：30 · 研究领域：Health, Environment, Cognitive Aging、Effects and risks of endocrine disrupting chemicals、Metabolomics and Mass Spectrometry Studies

BACKGROUND: Environmental contaminants (ECs) are increasingly recognized as crucial drivers of dyslipidemia and cardiovascular disease (CVD), but the comprehensive impact spectrum and interlinking mechanisms remain uncertain. OBJECTIVES: We aimed to systematically evaluate the association between exposure to 80 ECs across seven divergent categories and markers of dyslipidemia and investigate their underpinning biomolecular mechanisms via an unbiased integrative approach of internal chemical exposome and multi-omics. METHODS: and dyslipidemia markers. Weighted quantile sum regression was used to assess the mixture effects and relative contributions. Multi-omics profiling, causal inference model, and pathway analysis were conducted to interpret the mediating biomolecules and underlying mechanisms. Examination of cytokines and electrocardiograms was further conducted to validate the observed associations and biomolecular pathways. RESULTS: Eight main ECs [1-naphthalene, 1-pyrene, 2-fluorene, dibutyl phosphate, tri-phenyl phosphate, mono-(2-ethyl-5-hydroxyhexyl) phthalate, chromium, and vanadium] were significantly associated with most dyslipidemia markers. Multi-omics indicated that the associations were mediated by endogenous biomolecules and pathways, primarily pertinent to CVD, inflammation, and metabolism. Clinical measures of cytokines and electrocardiograms further cross-validated the association of these exogenous ECs with systemic inflammation and cardiac function, demon...