Radiation-Induced Intestinal Injury: Molecular Mechanisms and Therapeutic Status

作者：D. Gao, Heng Zhang, Wanjun Sun, Huaqing Wang, Hui Wang, Hui Wang, Hui Wang · 发表于：DNA and Cell Biology · 年份：2024 · DOI：10.1089/dna.2024.0105 · 被引用次数：31 · 研究领域：Effects of Radiation Exposure、Radiation Therapy and Dosimetry、Vitamin C and Antioxidants Research

Radiation-induced intestinal injury is one of the most common intestinal complications caused by pelvic and abdominal tumor radiotherapy, severely impacting patients' quality of life. Ionizing radiation, while killing tumor cells, inevitably damages healthy tissue. Radiation-induced enteropathy results from radiation therapy-induced intestinal tissue damage and inflammatory responses. This damage involves various complex molecular mechanisms, including cell apoptosis, oxidative stress, release of inflammatory mediators, disruption of immune responses, and imbalance of intestinal microbiota. A thorough understanding of these molecular mechanisms is crucial for developing effective prevention and treatment strategies.