Effects of nano-Rhodiola rosea combined with treadmill exercise on anti-exercise fatigue in rats

作者：Jibing Wang, Guoyan Zhang, Duona Wang, Yuanyuan Yan, Qin Yang · 发表于：Frontiers in Nutrition · 年份：2024 · DOI：10.3389/fnut.2024.1446944 · 被引用次数：9 · 研究领域：Medicinal Plants and Bioactive Compounds、Apelin-related biomedical research、Pharmacological Effects of Natural Compounds

Objective To explore the potential strategies and mechanisms for enhancing the bioavailability of Rhodiola rosea . Methods 36 Sprague–Dawley rats (8-weeks-old) were randomly assigned to six groups ( n = 6 per group). Groups I and II received nano-dose forms of R. rosea , groups III and IV received normal dose form of R. rosea , and groups V and VI served as distilled water control groups. Groups II, IV, and VI were combined with moderate -intensity treadmill exercise. Each group received a daily gavage with 0.5 mL of nano - R. rosea solution (0.01 mg/mL), normal R. rosea solution, and distilled water. All rats were subjected to exhaustive swimming after 4 weeks. Outcome measures include GSH-px activity, T-AOC activity, MDA content, hepatic glycogen content, and T-SOD activity. Results For plasma MDA content, group I was lower than group III ( p &lt; 0.01) and group V ( p &lt; 0.01), group II was lower than group III ( p &lt; 0.01), group VI was higher than group II ( p &lt; 0.05) and group IV ( p &lt; 0.05). For plasma T-AOC activity, group II was higher than group VI ( p &lt; 0.01). For plasma GSH-px activity, group I was lower than group IV ( p &lt; 0.05), groups II, III, and IV were higher than group V ( p &lt; 0.05), and group V was lower than that of group VI ( p &lt; 0.05). For T-SOD activity of quadriceps muscle, groups I and III were higher than that in group V ( p &lt; 0.05). Conclusion R. rosea has a positive effect on anti-ex...