Mitochondria-encoded peptide MOTS-c participates in plasma membrane repair by facilitating the translocation of TRIM72 to membrane

作者：Hong Jia, Lyu-Chen Zhou, Yongfeng Chen, Wei Zhang, Qi Wei, Peng George Wang, Xiao Huang, Jianwei Guo, Wai-Fang Hou, Ranran Zhang, Jing‐Jun Zhou, Dawei Zhang · 发表于：Theranostics · 年份：2024 · DOI：10.7150/thno.100321 · 被引用次数：4 · 研究领域：Autophagy in Disease and Therapy、Mitochondrial Function and Pathology、GDF15 and Related Biomarkers

MOTS-c/TRIM72-mediated membrane integrity improvement participates in mitochondria-triggered membrane repair. An interaction between MOTS-c and plasma lipid contributes to the fusion of vesicles with membrane. Our data provide a novel therapeutic strategy for rescuing organ function by facilitating membrane repair with MOTS-c.