Chemically protected sodium butyrate supplementation improves anti-inflammatory and antioxidant capacities potentially through modulating gut microbiota and short-chain fatty acids levels in piglets

作者：Fan Wan, Xiaobin Wen, Huaibao Zhao, Shanlong Tang, Mengyu Wang, Bao Yi, Liang Chen, Yang Lu, Ruqing Zhong, Hongfu Zhang · 发表于：Journal of Functional Foods · 年份：2024 · DOI：10.1016/j.jff.2024.106434 · 被引用次数：11 · 研究领域：Gut microbiota and health、Diet and metabolism studies、Probiotics and Fermented Foods

• CSB supplementation improved anti-inflammatory and antioxidant capacities in piglets. • CSB supplementation improved intestinal health through modulate gut microbiota in piglets. • CSB supplementation dynamic changes of SCFAs in the gastrointestinal tract of piglets. Chemically protected sodium butyrate (CSB) is a novel form of sodium butyrate. This study aimed to investigate the effect of CSB supplementation on the gut mucosal immune, gut microbiota, and SCFAs in piglets. Results showed that supplementation with 2000 mg/kg (high CSB, HCSB) improved the average daily gain by 18.5 %, while supplementation with 1000 mg/kg (low CSB, LCSB) improved it by 6.9 %. qPCR results indicated HCSB treatment dramatically upregulated the mRNA expression levels of IL-10 by 47.1 %, CAT by 17.4 %, SOD1 by 48.2 %, and Claudin-1 by 50 %. Additionally, the SCFAs-producing bacteria Parabacteroides and Eubacterium coprostanoligenes were increased by HCSB supplementation. The levels of acetic acid, propionic acid, butyric acid, isobutyric acid, valeric acid, and isovaleric acid were significantly enhanced in the jejunal, duodenal, cecal, and colonic chyme of piglets by HCSB supplementation. Collectively, CSB supplementation improves anti-inflammatory and antioxidant capacities potentially through modulating gut microbiota and SCFAs in piglets.