Targeted degradation of VEGF with bispecific aptamer-based LYTACs ameliorates pathological retinal angiogenesis

作者：Ping Zhou, Sai Zhang, Lin Li, Renshuai Zhang, Guizhi Guo, Yufei Zhang, Runa Wang, Miaoyuan Liu, Zhiyi Wang, Huijie Zhao, Guiwen Yang, Songbo Xie, Jie Ran · 发表于：Theranostics · 年份：2024 · DOI：10.7150/thno.98467 · 被引用次数：34 · 研究领域：interferon and immune responses、RNA Interference and Gene Delivery、Advanced biosensing and bioanalysis techniques

Our findings present a novel strategy for targeting VEGF degradation with an aptamer-based LYTAC system, effectively ameliorating pathological retinal angiogenesis. These results suggest that VED-LYTACs have potential as therapeutic agents for managing NODs.