Apoptotic vesicle-mediated senolytics requires mechanical loading

作者：Zhulin Xue, Yexiang Jiang, Bowen Meng, Lu Lu, Hao Meng, Yi Zhang, Songtao Shi, Zili Li, Xueli Mao · 发表于：Theranostics · 年份：2024 · DOI：10.7150/thno.98763 · 被引用次数：14 · 研究领域：RNA Interference and Gene Delivery、Phagocytosis and Immune Regulation、Cancer Research and Treatments

This study identified a previously unknown role of mechanical force in maintaining apoptotic homeostasis and eliminating senescent cells. Systemic infusion of mesenchymal stem cell-derived apoVs can effectively rescue apoptotic resistance and eliminate senescent cells in mechanical unloading mice.