Antibacterial Indole‐Diterpenoid Alkaloids from the Marine Fungus Penicillium sp. ZYX‐Z‐718

作者：Li Yang, Miao‐Miao Quan, Qing‐Yun Ma, Qing-Yi Xie, Cui‐Juan Gai, Hao‐Fu Dai, Yu-E Hao, You‐Xing Zhao, You‐Xing Zhao · 发表于：Chemistry & Biodiversity · 年份：2024 · DOI：10.1002/cbdv.202401871 · 被引用次数：5 · 研究领域：Microbial Natural Products and Biosynthesis、Marine Sponges and Natural Products、Microbial Metabolism and Applications

Two new indole-diterpenoids, penpaxilloids F and G (1 and 2), along with 11 known analogues (3-13), were isolated from the marine fungus Penicillium sp. ZYX-Z-718. The structures of the new compounds were identified by extensive spectroscopic analyses including HR-ESI-MS, UV, and NMR, as well as theoretical NMR chemical shifts and ECD calculations. Compounds 6 and 10 showed antibacterial activity against Gram-positive bacteria including Staphylococcus aureus, Bacillus subtilis, and MRSA with MIC values ranging from 16.0-32.0 μg/mL.