Intrinsic ADRB2 inhibition improves CAR-T cell therapy efficacy against prostate cancer

作者：Iqra Ajmal, Muhammad Asad Farooq, Yixin Duan, Jie Yao, Yaoxin Gao, Xinhui Hui, Yujia Ge, Yiran Chen, Yaojun Ren, Bingtan Du, Wenzheng Jiang · 发表于：Molecular Therapy · 年份：2024 · DOI：10.1016/j.ymthe.2024.08.028 · 被引用次数：35 · 研究领域：CAR-T cell therapy research、Immune Cell Function and Interaction、Cancer Immunotherapy and Biomarkers

-CAR-T cells performed better than conventional CAR-T cells in eradicating prostate tumors. The study provides the basis for future clinical and translational CAR-T cell research to focus on adrenergic stress-mediated challenges in the tumor microenvironment of stressed tumors.