Recombinant collagen for the repair of skin wounds and photo-aging damage

作者：Taishan Liu, Jiayun Hao, Huan Lei, Yanru Chen, Lin Liu, Liping Jia, Juan Gu, Huaping Kang, Jingjing Shi, Jing He, Yangbin Song, Yuqi Tang, Daidi Fan · 发表于：Regenerative Biomaterials · 年份：2024 · DOI：10.1093/rb/rbae108 · 被引用次数：32 · 研究领域：Wound Healing and Treatments、Skin Protection and Aging、Collagen: Extraction and Characterization

The skin, being the body's primary defense mechanism, is susceptible to various injuries such as epidermal wounds, natural aging, and ultraviolet-induced damage. As a result, there is growing interest in researching skin repair methods. Traditional animal-derived collagen, widely available on the market, poses risks due to its immunogenicity and potential for viral contamination. In contrast, recombinant collagen sourced from human genes offers a safer alternative. To investigate the potential of human recombinant collagen in skin repair, our research team applied two types, type I human collagen (Col I) and CF-1552(I), to two different skin injury models: a wound-healing model and a photo-aging model. Our findings indicate that both Col I and CF-1552(I) effectively enhance wound healing and repair skin damaged by ultraviolet exposure. Notably, CF-1552(I) showed effects comparable to Col I in promoting cell proliferation in the wound-healing model and increasing malondialdehyde content in the photo-aging model, suggesting that CF-1552(I) may offer greater potential for skin repair compared to the larger Col I molecule.