AOC3 accelerates lung metastasis of osteosarcoma by recruiting tumor-associated neutrophils, neutrophil extracellular trap formation and tumor vascularization

作者：Luxia Qi, Tian Gao, Chujie Bai, Zhanfei Guo, Linjing Zhou, Xiaodong Yang, Zhengfu Fan, Guifang Zhang · 发表于：Heliyon · 年份：2024 · DOI：10.1016/j.heliyon.2024.e37070 · 被引用次数：7 · 研究领域：Microbial metabolism and enzyme function、Neutrophil, Myeloperoxidase and Oxidative Mechanisms、Cancer, Hypoxia, and Metabolism

experiments. The promoting effect of AOC3 on tumor lung metastasis was achieved by recruiting tumor neutrophils. Activated NETs could up-regulate the metastatic ability of OS cells. Tumor neovascularization also played a role in metastasis, and AOC3 supported tumor neovascularization. AOC3 accelerates lung metastasis of OS by recruiting tumor-related neutrophils and utilizing NETs and tumor vascularization formation.