Degradation of andrographolide in Andrographis paniculata over 1 year storage

作者：Md. Tanvin Ahammed, Md Zakir Sultan, Md. Sabbir Hossain, Mamun Al Mahtab, Sitesh Chandra Bachar · 发表于：Phytochemical Analysis · 年份：2024 · DOI：10.1002/pca.3441 · 被引用次数：5 · 研究领域：Andrographolide Research and Applications、Traditional Chinese Medicine Analysis、Ginseng Biological Effects and Applications

INTRODUCTION: Andrographolide is a bioactive component found in the medicinal herb Andrographis paniculata (Burm. f.) Wall. ex Nees (Family-Acanthaceae) is well-known for its ability to cure liver disorders and as a bitter tonic. OBJECTIVE: In this study, the rate of degradation of andrographolide was examined over the course of a year of storage. MATERIALS AND METHODS: New and old (1-year storage) A. paniculata powder samples were used in the study. High-performance liquid chromatography (HPLC) was used to assess the concentration of andrographolide after its extraction using ethanol as the solvent. RESULTS: The findings demonstrated a 69.26% progressive deterioration of andrographolide over the storage period. Temperature and crystallinity are two factors that affect how quickly andrographolide degrades. CONCLUSION: The results emphasize how crucial it is to retain the effectiveness of A. paniculata extract by avoiding prolonged storage or by providing ideal storage conditions.