Body Mass Index and Risk of Colorectal Cancer Incidence and Mortality in Asia

作者：Pedram Paragomi, Zhongjie Zhang, Sarah Krull Abe, Md. Rashedul Islam, Md. Shafiur Rahman, Eiko Saito, Xiao-Ou Shu, Bashir Dabo, Yen Thi‐Hai Pham, Yu Chen, Yu-Tang Gao, Woon‐Puay Koh, Norie Sawada, Reza Malekzadeh, Ritsu Sakata, Atsushi Hozawa, Jeongseon Kim, Seiki Kanemura, Chisato Nagata, San‐Lin You, Hidemi Ito, Sue K. Park, Jian‐Min Yuan, Wen-Harn Pan, Wanqing Wen, Renwei Wang, Hui Cai, Shoichiro Tsugane, Akram Pourshams, Yumi Sugawara, Keiko Wada, Chien‐Jen Chen, Isao Oze, Aesun Shin, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You‐Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang, Hung N. Luu · 发表于：JAMA Network Open · 年份：2024 · DOI：10.1001/jamanetworkopen.2024.29494 · 被引用次数：29 · 研究领域：Cancer Risks and Factors、Colorectal Cancer Screening and Detection、Global Cancer Incidence and Screening

Importance: The global burden of obesity is increasing, as are colorectal cancer (CRC) incidence and mortality. Objectives: To assess the association between body mass index (BMI) and risks of incident CRC and CRC-related death in the Asian population. Design, Setting, and Participants: This cohort study includes data pooled from 17 prospective cohort studies included in The Asia Cohort Consortium. Cohort enrollment was conducted from January 1, 1984, to December 31, 2002. Median follow-up time was 15.2 years (IQR, 12.1-19.2 years). Data were analyzed from January 15, 2023, through January 15, 2024. Exposure: Body mass index, calculated as weight in kilograms divided by height in meters squared. Main Outcomes and Measures: The primary outcomes were CRC incidence and CRC-related mortality. The risk of events is reported as adjusted hazard ratios (AHRs) and 95% CIs for incident CRC and death from CRC using the Cox proportional hazards regression model. Results: To assess the risk of incident CRC, 619 981 participants (mean [SD] age, 53.8 [10.1] years; 52.0% female; 11 900 diagnosed incident CRC cases) were included in the study, and to assess CRC-related mortality, 650 195 participants (mean [SD] age, 53.5 [10.2] years; 51.9% female; 4550 identified CRC deaths) were included in the study. A positive association between BMI and risk of CRC was observed among participants with a BMI greater than 25.0 to 27.5 (AHR, 1.09 [95% CI, 1.03-1.16]), greater than 27.5 to 30.0 (AHR, 1.19 [9...