Psychiatric Symptoms, Cognition, and Symptom Severity in Children

作者：Adam Pines, Leonardo Tozzi, Claire Bertrand, Arielle S. Keller, Xue Zhang, Susan Whitfield‐Gabrieli, Trevor Hastie, Bart Larsen, John E. Leikauf, Leanne M. Williams · 发表于：JAMA Psychiatry · 年份：2024 · DOI：10.1001/jamapsychiatry.2024.2399 · 被引用次数：12 · 研究领域：Schizophrenia research and treatment、Attention Deficit Hyperactivity Disorder、Bipolar Disorder and Treatment

Importance: Mental illnesses are a leading cause of disability globally, and functional disability is often in part caused by cognitive impairments across psychiatric disorders. However, studies have consistently reported seemingly opposite findings regarding the association between cognition and psychiatric symptoms. Objective: To determine if the association between general cognition and mental health symptoms diverges at different symptom severities in children. Design, Setting, and Participants: A total of 5175 children with complete data at 2 time points assessed 2 years apart (aged 9 to 11 years at the first assessment) from the ongoing Adolescent Brain and Cognitive Development (ABCD) study were evaluated for a general cognition factor and mental health symptoms from September 2016 to August 2020 at 21 sites across the US. Polynomial and generalized additive models afforded derivation of continuous associations between cognition and psychiatric symptoms across different ranges of symptom severity. Data were analyzed from December 2022 to April 2024. Main Outcomes and Measures: Aggregate cognitive test scores (general cognition) were primarily evaluated in relation to total and subscale-specific symptoms reported from the Child Behavioral Checklist. Results: The sample included 5175 children (2713 male [52.4%] and 2462 female [47.6%]; mean [SD] age, 10.9 [1.18] years). Previously reported mixed findings regarding the association between general cognition and symptoms ma...