Omega-3 PUFAs slow organ aging through promoting energy metabolism

作者：Yabing Xiong, Xiaolong Li, Jiafeng Liu, Pei Luo, Haixia Zhang, Hongwei Zhou, Xian Ling, Meijia Zhang, Liang Ye, Qiurong Chen, Chaofeng Xing, Fanghong Li, Jinhua Miao, Weiwei Shen, Shan Zhou, Xiaoxu Wang, Fan Fan Hou, Youhua Liu, Kun‐Ling Ma, Allan Z. Zhao, Lili Zhou · 发表于：Pharmacological Research · 年份：2024 · DOI：10.1016/j.phrs.2024.107384 · 被引用次数：26 · 研究领域：Fatty Acid Research and Health、Adipose Tissue and Metabolism、Diet and metabolism studies

Energy metabolism disorder, mainly exhibiting the inhibition of fatty acid degradation and lipid accumulation, is highly related with aging acceleration. However, the intervention measures are deficient. Here, we reported Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs), especially EPA, exerted beneficial effects on maintaining energy metabolism and lipid homeostasis to slow organ aging. As the endogenous agonist of peroxisome proliferator-activated receptor α (PPARα), Omega-3 PUFAs significantly boosted fatty acid β-oxidation and ATP production in multiple aged organs. Consequently, Omega-3 PUFAs effectively inhibited age-related pathological changes, preserved organ function, and retarded aging process. The beneficial effects of Omega-3 PUFAs were also testified in mfat-1 transgenic mice, which spontaneously generate abundant endogenous Omega-3 PUFAs. In conclusion, our study innovatively demonstrated Omega-3 PUFAs administration in diet slow aging through promoting energy metabolism. The supplement of Omega-3 PUFAs or fat-1 transgene provides a promising therapeutic approach to promote healthy aging in the elderly.