The prognostic impact of psychiatric intervention on alcohol-associated liver disease: The UK Biobank cohort study

作者：Keungmo Yang, Sung Hwan Kim, Hyun Yang, Sheng‐Min Wang, Bumseok Jeong, Hyun Kook Lim, Si Hyun Bae · 发表于：Clinical and Molecular Hepatology · 年份：2024 · DOI：10.3350/cmh.2024.0278 · 被引用次数：3 · 研究领域：Alcohol Consumption and Health Effects、Liver Disease Diagnosis and Treatment、Alcoholism and Thiamine Deficiency

BACKGROUND/AIMS: Alcohol-associated liver disease (ALD) is a public health concern. ALD patients often have psychiatric comorbidities, but the effects of psychiatric interventions on ALD are not well-established. This study explores the prognostic impact of psychiatric intervention on ALD within UK Biobank cohort. METHODS: This population-based study included 2,417 ALD patients from the UK Biobank cohort. Psychiatric intervention was defined by a consultation with psychiatrists during hospitalization or a history of medication related to alcohol use disorder and psychiatric comorbidities. Survival analysis was conducted, incorporating propensity score matching (PSM), to precisely assess the impact of psychiatric intervention. RESULTS: Among 2,417 ALD patients, those with F10 (mental disorders due to alcohol) codes had poorer survival outcomes. Psychiatric intervention significantly improved the outcomes of both all-cause and liver-related mortality and reduced the incidence of liver cirrhosis. In subgroup or 2-year landmark analyses, psychiatric intervention consistently showed a survival benefit in ALD patients. In the multivariate analysis, psychiatric intervention was identified as a favorable prognostic factor (hazard ratio, 0.780; P=0.002 after PSM). CONCLUSION: This study demonstrates the favorable effect of psychiatric intervention in ALD patients with psychiatric comorbidities. These findings emphasize the importance of integrated management for ALD patients to addres...