Prognostic Value of Resting Left Ventricular Sphericity Indexes in Coronary Artery Disease With Preserved Ejection Fraction

作者：Ping Wu, Yuting Zhao, X Q Guo, Xia Liu, Yingqi Hu, Yuxin Xiao, Xu Li, Nan Huang, Yuanyuan Li, Y. Wang, Tailin Ren, Qiuyan Wu, Ruonan Wang, Xiaoli Zhang, Zhifang Wu, Sijin Li · 发表于：Journal of the American Heart Association · 年份：2024 · DOI：10.1161/jaha.123.032169 · 被引用次数：7 · 研究领域：Cardiac Imaging and Diagnostics、Cardiovascular Function and Risk Factors、Cardiovascular Disease and Adiposity

Background Adverse left ventricular remodeling is a significant cardiovascular predictor for patients with coronary artery disease and preserved left ventricular ejection fraction (LVEF). However, the remodeling indexes reflecting left ventricular spherization by myocardial perfusion imaging are underexplored. Methods and Results 727 patients (mean age 59.8±13.5 years, 329 women) diagnosed or suspected coronary artery disease with preserved LVEF who underwent resting myocardial perfusion imaging were retrospectively enrolled. The myocardial perfusion imaging findings including the total perfusion deficit and sphericity indexes (shape index (SI) and eccentricity index (EI) obtained from gated (QGS) and non‐gated (QPS) images) were collected. Major adverse cardiovascular events (MACE) were followed up for 45.1±22.0 months. All patients were divided into 4 subgroups based on total perfusion deficit at 10% and LVEF at 65%. Univariable comparative analyses were performed in 5 cohorts (all patients and 4 subgroups). Patients who experienced MACE displayed higher SI and/or lower EI (all P <0.05). Kaplan–Meier survival analyses suggested significant differences for SI QPS in all 5 cohorts, for EI QPS and EI QGS in 4 cohorts, and for end‐systolic and end‐diastolic SI QGS in 3 cohorts (all P <0.05). Multivariate Cox analysis showed that abnormal SI and EI remained statistically significant predictors for MACE after adjusting for total perfusion deficit, LVEF, and other confoundin...