Essential Roles of PIEZO1 in Mammalian Cardiovascular System: From Development to Diseases

作者：Chengjiang Jin, Sheng’an Su, Shuo Yu, Yue Zhang, Kai‐Jie Chen, Meixiang Xiang, Hong Ma · 发表于：Cells · 年份：2024 · DOI：10.3390/cells13171422 · 被引用次数：18 · 研究领域：Erythrocyte Function and Pathophysiology、Blood properties and coagulation、Cell death mechanisms and regulation

Mechanical force is the basis of cardiovascular development, homeostasis, and diseases. The perception and response of mechanical force by the cardiovascular system are crucial. However, the molecular mechanisms mediating mechanotransduction in the cardiovascular system are not yet understood. PIEZO1, a novel transmembrane mechanosensitive cation channel known for its regulation of touch sensation, has been found to be widely expressed in the mammalian cardiovascular system. In this review, we elucidate the role and mechanism of PIEZO1 as a mechanical sensor in cardiovascular development, homeostasis, and disease processes, including embryo survival, angiogenesis, cardiac development repair, vascular inflammation, lymphangiogenesis, blood pressure regulation, cardiac hypertrophy, cardiac fibrosis, ventricular remodeling, and heart failure. We further summarize chemical molecules targeting PIEZO1 for potential translational applications. Finally, we address the controversies surrounding emergent concepts and challenges in future applications.