Sarcopenia Is a Risk Factor for Postoperative Complications Among Older Adults With Inflammatory Bowel Disease

作者：Ria Minawala, Michelle Kim, Olivia Delau, Ghoncheh Ghiasian, Anna Sophia McKenney, Andre Da Luz Moreira, Joshua Chodosh, Mara McAdams‐DeMarco, Dorry L. Segev, Samrachana Adhikari, John Dodson, Aasma Shaukat, Bari Dane, Adam S. Faye · 发表于：Inflammatory Bowel Diseases · 年份：2024 · DOI：10.1093/ibd/izae187 · 被引用次数：13 · 研究领域：Nutrition and Health in Aging、Inflammatory Bowel Disease、Clinical Nutrition and Gastroenterology

BACKGROUND: Sarcopenia has been associated with adverse postoperative outcomes in older age cohorts, but has not been assessed in older adults with inflammatory bowel disease (IBD). Further, current assessments of sarcopenia among all aged individuals with IBD have used various measures of muscle mass as well as cutoffs to define its presence, leading to heterogeneous findings. METHODS: In this single-institution, multihospital retrospective study, we identified all patients aged 60 years and older with IBD who underwent disease-related intestinal resection between 2012 and 2022. Skeletal Muscle Index (SMI) and Total Psoas Index (TPI) were measured at the superior L3 endplate on preoperative computed tomography scans and compared through receiver operating characteristic curve. We then performed multivariable logistic regression to assess risk factors associated with an adverse 30-day postoperative outcome. Our primary outcome included a 30-day composite of postoperative mortality and complications, including infection, bleeding, cardiac event, cerebrovascular accident, acute kidney injury, venous thromboembolism, reoperation, all-cause rehospitalization, and need for intensive care unit-level care. RESULTS: A total of 120 individuals were included. Overall, 52% were female, 40% had ulcerative colitis, 60% had Crohn's disease, and median age at time of surgery was 70 years (interquartile range: 65-75). Forty percent of older adults had an adverse 30-day postoperative outcome,...