Clinical and biobehavioral phenotypic assessments and data harmonization for the RE-JOIN research consortium: Recommendations for common data element selection

作者：Yenisel Cruz‐Almeida, Bella Mehta, Nele A Haelterman, Alisa J. Johnson, Chloe Heiting, Malin Ernberg, Dana E. Orange, Martin Lotz, Jacqueline Boccanfuso, Shad B. Smith, Marlena Pela, Jyl Boline, Miguel Otero, Kyle D. Allen, Daniel Pérez, Christopher R. Donnelly, Alejandro J. Almarza, Merissa Olmer, Henah Balkhi, Joost Wagenaar, Maryann E. Martone · 发表于：Neurobiology of Pain · 年份：2024 · DOI：10.1016/j.ynpai.2024.100163 · 被引用次数：9 · 研究领域：Temporomandibular Joint Disorders、Osteoarthritis Treatment and Mechanisms、Orthodontics and Dentofacial Orthopedics

• The Restoring Joint Health and Function to Reduce Pain (RE-JOIN) Consortium is part of the Helping to End Addiction Long-term® (HEAL) Initiative with the over-arching goal to define how joint pain-mediating neurons innervate different articular and peri -articular tissues employing the latest neuroscience approaches. • We aim to elucidate the human data gathered by the RE-JOIN consortium, as well as to expound upon its underlying rationale and the methodologies and protocols for harmonization and standardization that have been instituted by the RE-JOIN Consortium. • The harmonized phenotypic information obtained will significantly enhance our understanding of the neurobiology of the pain-pathology relationships in humans, providing valuable insights for comparison with pre-clinical models. The Restoring Joint Health and Function to Reduce Pain (RE-JOIN) Consortium is part of the Helping to End Addiction Long-term® (HEAL) Initiative. HEAL is an ambitious, NIH-wide initiative to speed scientific solutions to stem the national opioid public health crisis. The RE-JOIN consortium’s over-arching goal is to define how chronic joint pain-mediating neurons innervate different articular and peri -articular tissues, with a focus on the knee and temporomandibular joints (TMJ) across species employing the latest neuroscience approaches. The aim of this manuscript is to elucidate the human data gathered by the RE-JOIN consortium, as well as to expound upon its underlying rationale and th...