The attributable mortality, length of stay, and health care costs of methicillin-resistant Staphylococcus aureus infections in Singapore

作者：Yiying Cai, Edwin C. Philip, Shalvi Arora, Jean Xiang Ying Sim, Weien Chow, Nuraini Nazeha, Sean Whiteley, Daniel Tiang, Siow Leng Neo, Weiwei Hong, Indumathi Venkatachalam, Nicholas Graves · 发表于：IJID Regions · 年份：2024 · DOI：10.1016/j.ijregi.2024.100427 · 被引用次数：5 · 研究领域：Antimicrobial Resistance in Staphylococcus、Infection Control in Healthcare、Antibiotic Use and Resistance

Objectives: (MRSA) infections in Singapore. Methods: We conducted a retrospective study in a hospital in Singapore from 2018 to 2022. Patients with MRSA infections were matched 1:1:3 to patients with MRSA colonization and patients without MRSA by age, gender, specialty, and intensive care admission, respectively. A multi-state model was used to derive excess LOS and mortality hazard ratios. The attributable cost of infections was estimated in 2022 Singapore dollars (SGDs) from the health care perspective. Results: We matched 536 patients with MRSA infections to 536 patients with MRSA colonization, and to 1608 patients without MRSA. The excess LOS due to MRSA infection was 2.11 (95% confidence interval [CI] 2.05-2.17) days compared with MRSA colonization and 3.75 (95% CI 3.69-3.80) days compared with no MRSA, which translated to an excess cost of SGD $1825 and SGD $3238, respectively. Of the different MRSA infection types, pneumonia had the highest mortality risk (hazard ratio 4.13; 95% CI 2.28-7.50) compared with patients without MRSA. Conclusions: MRSA infections increased hospital LOS and health care costs in Singapore. Our estimates can inform future economic analyses of management strategies against MRSA.