Deep serum lipidomics identifies evaluative and predictive biomarkers for individualized glycemic responses following low-energy diet-induced weight loss: a PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World (PREVIEW) substudy

作者：Yingxin Celia Jiang, Kaitao Lai, Roslyn Muirhead, Long Hoa Chung, Yu Huang, Elizaveta James, Xin Tracy Liu, Julian K. Wu, Fiona Atkinson, Shuang Yan, Mikael Fogelholm, Anne Raben, Anthony S. Don, Jing Sun, Jennie Brand‐Miller, Yanfei Qi · 发表于：American Journal of Clinical Nutrition · 年份：2024 · DOI：10.1016/j.ajcnut.2024.08.015 · 被引用次数：11 · 研究领域：Metabolomics and Mass Spectrometry Studies、Diet and metabolism studies、Diabetes, Cardiovascular Risks, and Lipoproteins

BACKGROUND: Weight loss through lifestyle interventions, notably low-energy diets, offers glycemic benefits in populations with overweight-associated prediabetes. However, >50% of these individuals fail to achieve normoglycemia after weight loss. Circulating lipids hold potential for evaluating dietary impacts and predicting diabetes risk. OBJECTIVES: This study sought to identify serum lipids that could serve as evaluative or predictive biomarkers for individual glycemic changes following diet-induced weight loss. METHODS: We studied 104 participants with overweight-associated prediabetes, who lost ≥8% weight via a low-energy diet over 8 wk. High-coverage lipidomics was conducted in serum samples before and after the dietary intervention. The lipidomic recalibration was assessed using differential lipid abundance comparisons and partial least squares discriminant analyses. Associations between lipid changes and clinical characteristics were determined by Spearman correlation and Bootstrap Forest of ensemble machine learning model. Baseline lipids, predictive of glycemic parameters changes postweight loss, were assessed using Bootstrap Forest analyses. RESULTS: We quantified 439 serum lipid species and 9 related organic acids. Dietary intervention significantly reduced diacylglycerols, ceramides, lysophospholipids, and ether-linked phosphatidylethanolamine. In contrast, acylcarnitines, short-chain fatty acids, organic acids, and ether-linked phosphatidylcholine increased sign...