Identification of a prognostic disulfidptosis-related gene signature in hepatocellular cancer

作者：Jinhong Zhu, Yan Wu, Pengyu Ji, Jun Qi, Xuekun Yang, Christine Pocha, Francisco Tustumi, Tiago Biachi De Castria · 发表于：Journal of Gastrointestinal Oncology · 年份：2024 · DOI：10.21037/jgo-24-522 · 被引用次数：5 · 研究领域：Ferroptosis and cancer prognosis、Cancer Immunotherapy and Biomarkers、Hepatocellular Carcinoma Treatment and Prognosis

Background: Disulfidptosis regulate various biological processes in cancer. However, there is limited research on the genes related to disulfidptosis in predicting the prognosis of hepatocellular carcinoma (HCC). We aimed to develop a reliable disulfidptosis-related gene signature, which will characterize different HCC subtypes and predict their prognosis. Methods: The Cancer Genome Atlas (TCGA)-HCC dataset, comprising RNA sequencing data and clinical information, was obtained from the TCGA database. The crucial disulfidptosis-related genes were selected for bioinformatic analysis in HCC. HCC tumor classification was established through a consistent cluster analysis. The prognosis and immune-cell infiltration were investigated in association with a disulfidptosis-related HCC model. Results: In TCGA-HCC patients, a total of 3,621 prognostic genes and 30 key prognostic disulfidptosis-related genes were identified. Using key prognostic disulfidptosis-related genes, TCGA-HCC patients were categorized into low- and high-risk clusters. The upregulated differentially expressed genes (DEGs) in high-risk cluster 1 (C1) could significantly impact cell cycle, DNA replication, and the p53 signaling pathway, whereas the pathways associated with the downregulated DEGs in high-risk C1 could significantly impact metabolism of xenobiotics by cytochrome P450, the PPAR signaling pathway, and tyrosine metabolism. Furthermore, the immune activity of the high-risk C1 group was different to that of...