Association between systemic immune-inflammation index and serum neurofilament light chain: a population-based study from the NHANES (2013–2014)

作者：Xinyu Liu, Yue Yang, Qiutong Lu, Jianshu Yang, Jing Yuan, Jun Hu, Yue Tu · 发表于：Frontiers in Neurology · 年份：2024 · DOI：10.3389/fneur.2024.1432401 · 被引用次数：10 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Platelet Disorders and Treatments、Adipokines, Inflammation, and Metabolic Diseases

Background The systemic immune-inflammation index (SII) is a novel inflammatory marker used to assess the immune-inflammatory status of the human body. The systemic immune inflammation has an interplay and mutual relationship with neurological disorders. Serum neurofilament light chain (sNfL) is widely regarded as a potential biomarker for various neurological diseases. The study aimed to examine the association between SII and sNfL. Methods This cross-sectional investigation was conducted in a population with complete data on SII and sNfL from the 2013–2014 National Health and Nutrition Examination Survey (NHANES). The SII was calculated by dividing the product of platelet count and neutrophil count by the lymphocyte count. Multivariate linear regression models and smooth curves were used to explore the linear connection between SII and sNfL. Sensitivity analyses, interaction tests, and diabetes subgroup smoothing curve fitting were also performed. Results A total of 2,025 participants were included in our present research. SII showed a significant positive association with the natural logarithm-transformed sNfL (ln-sNfL) in crude model [0.17 (0.07, 0.28)], partially adjusted model [0.13 (0.03, 0.22)], and fully adjusted model [0.12 (0.02, 0.22)]. In all participants, the positive association between SII and ln-sNfL served as a linear relationship, as indicated by a smooth curve. Interaction tests showed that age, gender, BMI, hypertension, and diabetes did not have a signif...