Association of the visceral fat metabolic score with osteoarthritis risk: a cross-sectional study from NHANES 2009–2018

作者：Hongfei Xue, Longyao Zhang, Jiankang Xu, Kuiliang Gao, Chao Zhang, Lingling Jiang, Sirui Lv, Chao Zhang · 发表于：BMC Public Health · 年份：2024 · DOI：10.1186/s12889-024-19722-0 · 被引用次数：22 · 研究领域：Diabetes, Cardiovascular Risks, and Lipoproteins、Osteoarthritis Treatment and Mechanisms、Nutritional Studies and Diet

BACKGROUND: Currently, obesity has been recognized to be an independent risk factor for osteoarthritis (OA), and the Metabolic Score for Visceral Fat (METS-VF) has been suggested to be potentially more accurate than body mass index (BMI) in the assessment of obesity. Nevertheless, the correlation of METS-VF with OA has not been obviously revealed yet. Therefore, this study aimed to delve into the potential relationship between METS-VF and OA. METHODS: By examining data from the NHANES (2009–2018), weighted multivariate logistic regression analyses were used for assessing the correlation between METS-VF and OA. Subgroup analyses were then performed to validate the findings. Moreover, the nonlinear relationship between the two was assessed by restricted cubic spline (RCS). Receiver operating characteristic (ROC) curves were plotted to examine the diagnostic accuracy of METS-VF versus previous obesity index for OA. RESULTS: This study involved 7639 participants. According to our results, METS-VF was notably related to an elevated risk of OA, regardless of the METS-VF and the trend of positive association was more pronounced with the elevating METS-VF level (p for trend < 0.05). Subgroup analyses showed that the positive association between METS-VF and prevalence of osteoarthritis persisted in all populations with different characteristics, confirming its validity in all populations. Besides, RCS results showed a significant non-linear relationship between METS-VF and OA (p-non-l...