Responsiveness to Selective Laser Trabeculoplasty in Open-Angle Glaucoma and Ocular Hypertension

作者：Yangfan Yang, Kezheng Xu, Zidong Chen, Y. Zhang, Qiaona Ye, Yu-Tzu Ping, Yanmei Fan, Pingping Liu, Neil Nathwani, Yuzhen Jiang, Gus Gazzard, Minbin Yu, LiGHT China Trial Study Group, Mingkai Lin, Xing Liu, Xiulan Zhang, Jian Ge, Jingjing Huang, Yunlan Ling, Yimin Zhong, Chengguo Zuo, Jiangang Xu, Hui Xiao, Yixiang Huang, Hao Yuantao, Mingjie Deng, Yiming Ye, Zongyi Zhan, Shitong Huang, Yunzhen Wang, Yunzhi Xu · 发表于：JAMA Ophthalmology · 年份：2024 · DOI：10.1001/jamaophthalmol.2024.3133 · 被引用次数：6 · 研究领域：Glaucoma and retinal disorders、Corneal surgery and disorders、Retinal Diseases and Treatments

Importance: Selective laser trabeculoplasty (SLT) is becoming the recommended first choice in the treatment of open-angle glaucoma (OAG). However, whether repeat SLT can be recommended regardless of initial response remains controversial. Objective: To assess the potential of OAG and ocular hypertension (OHT) undergoing repeat laser to respond favorably to SLT, termed responsiveness to SLT. Design, Setting, and Participants: This post hoc analysis of the Laser in Glaucoma and Ocular Hypertension Trial in China (LiGHT China) was conducted from March 2015 to April 2023 in Zhongshan Ophthalmic Center. Of 1376 newly diagnosed OAG and OHT eyes of 771 adults in the original trial, 180 eyes of 105 participants were included in the present study, which underwent initial and repeat SLT as primary treatments. Exposures: Standard SLT was the primary treatment. Repeat SLT was the first choice of treatment escalation regardless of initial response. IOP reduction after SLT and the duration of effect were analyzed. The maximum reduction in IOP within 2 years after initial SLT and repeat SLT was used to identify potential nonresponsiveness. Main Outcomes and Measures: IOP reduction 2 months after SLT. Results: A total of 180 eyes from 105 Chinese participants (mean [SD] age, 45.6 [14.5] years; 58 [55.2%] male and 47 [44.8%] female) underwent repeat SLT. Initial SLT and repeat SLT were both associated with a reduction in IOP (mean, 4.5 mm Hg; 95% CI, 3.9 to 5.1; P < .001 and mean, 3.3 mm Hg; ...