An endo -functionalized molecular cage for selective potentiometric determination of creatinine

作者：Yu Lu, Song-Meng Wang, Suisui He, Qicheng Huang, Cheng‐Da Zhao, Shan Yu, Wei Jiang, Huan Yao, Lili Wang, Liu‐Pan Yang · 发表于：Chemical Science · 年份：2024 · DOI：10.1039/d4sc04950k · 被引用次数：20 · 研究领域：Analytical Chemistry and Sensors、Electrochemical sensors and biosensors、Molecular Sensors and Ion Detection

) through the formation of multiple C-H⋯O and N-H⋯N hydrogen bonds and cation⋯π interactions. ISEs prepared with this host show a Nernstian response to creatinine and exhibit excellent selectivity and a low detection limit of 0.95 μM. In addition, the creatinine levels in urine or plasma samples determined by our sensor are consistent with those analyzed using enzymatic assay on a Cobas c702. The method is simple, fast and accurate, and amenable to clinical detection of creatinine levels.