Cu(II)/Base Synergistic Promoted [2 + 1 + 3] Cyclization of Cyclic Ketones with α,β-Unsaturated Aldehydes/Ketones and NH4I to Access Fused Pyridines

作者：Lu Hao, Xinyu Li, Yifeng Ou, Peng Du, Shuang‐Feng Yin, Nobuaki Kambe, Renhua Qiu · 发表于：Organic Letters · 年份：2024 · DOI：10.1021/acs.orglett.4c02628 · 被引用次数：8 · 研究领域：Catalytic C–H Functionalization Methods、Synthesis and Catalytic Reactions、Sulfur-Based Synthesis Techniques

Herein, a practical three-component [2 + 1 + 3] cyclization of various cyclic ketones with α,β-unsaturated aldehydes/ketones and ammonium iodide (NH 4 I) to access highly functional fused pyridines has been developed. The features of this transformation include mild reaction conditions, readily available starting materials, and excellent chemoselectivity. This protocol is compatible with various functional groups, and the preliminary studies on the mechanism of the reaction are also provided.