Association Between Long-Term Exposure to Environmental Fine Particulate Matter and the Prevalence of Thyroid Disorders: A National Cross-Sectional Study in China

作者：Kaijie Yang, Cihang Lu, Kang Chen, Zhongyan Shan, Weiping Teng, Yongze Li, on behalf of the Thyroid Disorders, Iodine Status and Diabetes Epidemiological Survey Group · 发表于：Thyroid · 年份：2024 · DOI：10.1089/thy.2024.0286 · 被引用次数：13 · 研究领域：Air Quality and Health Impacts、Air Quality Monitoring and Forecasting、Vehicle emissions and performance

Background: Exposure to particles with an aerodynamic diameter of ≤2.5 μm (PM 2.5 ) is associated with the occurrence of thyroid dysfunction among pregnant women and neonates, but it is not known if this association occurs in the general population. We aimed to determine the association of prolonged exposure to PM 2.5 with the prevalence of thyroid disorders among adults in China. Methods: A nationally representative cross-sectional study of thyroid disorders, iodine status, and diabetes status was carried out in all 31 provinces across China from 2015 to 2017. In total, 73,900 adults aged 18 years and older were included. Serum concentrations of thyroid hormones, thyrotropin, and thyroid antibodies and the urine iodine concentration were measured. The environmental concentration of PM 2.5 for each participant’s residential address at a spatial resolution of 1 × 1 km was estimated. Results: The average long-term exposure to PM 2.5 at residential addresses was 66.41 μg/m 3 , ranging from 17.58 μg/m 3 to 120.40 μg/m 3 . Compared with that of individuals with lower exposure levels, the prevalence of thyroid diseases such as autoimmune thyroiditis and subclinical hypothyroidism was greater in those with PM 2.5 concentrations within the third quartile range (60.18 to 73.78 μg/m 3 ). Compared with those in the first quartile (17.58 to 46.38 μg/m 3 ), participants in the highest PM 2.5 quartile (73.78 to 120.40 μg/m 3 ) presented an increased risk of overt hypothyroidism (OR 1.23 [C...