Effects of computerized working memory training on neuroplasticity in healthy individuals: A combined neuroimaging and neurotransmitter study

作者：Peng Fang, Yuntao Gao, Yijun Li, Chenxi Li, Tian Zhang, Lin Wu, Yuanqiang Zhu, Yuanjun Xie · 发表于：NeuroImage · 年份：2024 · DOI：10.1016/j.neuroimage.2024.120785 · 被引用次数：15 · 研究领域：Functional Brain Connectivity Studies、Cognitive Abilities and Testing、Neural and Behavioral Psychology Studies

• Following an 8-week computerized working memory training, participants exhibited a notable alternation in the amplitude of low-frequency fluctuations (ALFF) in the fronto-occipital regions. • An increase in gray matter volume (GMV) was observed in the right dorsal superior frontal gyrus of the training group post-training. • Significant correlations was found between neuroimaging measures (ALFF and VBM) and the spatial patterns of neurotransmitters such as serotonin (5-HT), dopamine (DA), and N-methyl-D-aspartate (NMDA). Working memory (WM) is an essential cognitive function that underpins various higher-order cognitive processes. Improving WM capacity through targeted training interventions has emergered as a potential approach for enhancing cognitive abilities. The present study employed an 8-week regimen of computerized WM training (WMT) to investigate its effect on neuroplasticity in healthy individuals, utilizing neuroimaging data gathered both before and after the training. The key metrics assessed included the amplitude of low-frequency fluctuations (ALFF), voxel-based morphometry (VBM), and the spatial distribution correlations of neurotransmitter. The results indicated that post-training, compared to baseline, there was a reduction in ALFF in the medial superior frontal gyrus and an elevation in ALFF in the left middle occipital gyrus within the training group. In comparison to the control group, the training group also exhibited decreased ALFF in the anterior cing...