Paternal Preconception Hepatitis B Virus Infection and Risk of Congenital Heart Disease in Offspring

作者：Ying Yang, Meiya Liu, Jiancheng Han, Hanbin Wu, Chuanyu Zhao, Xinyi Lyu, Xuan Hu, Youhong Liu, Die Xu, Wenlu Xie, Jiaxin Huang, Siyu Wu, Jiaxin Li, Jueming Lei, Ya Zhang, Hongguang Zhang, Yuan He, Zuoqi Peng, Yuanyuan Wang, Haiping Shen, Qiaomei Wang, Yiping Zhang, Donghai Yan, Long Wang, Yihua He, Xu Ma · 发表于：Archives of Pediatrics and Adolescent Medicine · 年份：2024 · DOI：10.1001/jamapediatrics.2024.2680 · 被引用次数：14 · 研究领域：Hepatitis B Virus Studies、Cardiovascular Issues in Pregnancy、Hepatitis Viruses Studies and Epidemiology

Importance: Previous evidence suggests that maternal hepatitis B virus (HBV) infection during prepregnancy or pregnancy is associated with congenital heart diseases (CHDs) in offspring. However, the association of paternal HBV infection with CHDs is not well examined. Objective: To explore the association of paternal preconception HBV infection with CHDs in offspring. Design, Setting, and Participants: This retrospective cohort study used propensity score matching of data from the Chinese National Free Preconception Checkup Project (NFPCP) from January 1, 2010, to December 31, 2018. Male participants whose wives were aged 20 to 49 years, were uninfected with HBV, and successfully conceived within 1 year after prepregnancy examination were enrolled. Data were analyzed from March 2023 to February 2024. Exposures: The primary exposure was paternal preconception HBV infection status, including uninfected, previous infection (both serum hepatitis B surface antigen and hepatitis B envelope antigen negative), and new infection (serum hepatitis B surface antigen positive). Maternal HBV immune status was further classified as immune or susceptible. Main Outcomes and Measures: The main outcome was CHDs, which were collected from the birth defect registration card of the NFPCP. Logistic regression with robust error variances was used to estimate the association between paternal preconception HBV infection and CHDs in offspring. Results: A total of 6 675 540 couples participated in the N...