Phage therapy for bone and joint infections: A comprehensive exploration of challenges, dynamics, and therapeutic prospects

作者：Jiaze Peng, Jiaze Peng, Caopei Guo, Chengbing Yang, Lin Zhang, Fuyin Yang, Xianpeng Huang, Yang Yu, Tao Zhang, Jiachen Peng, Jiachen Peng · 发表于：Journal of Global Antimicrobial Resistance · 年份：2024 · DOI：10.1016/j.jgar.2024.07.007 · 被引用次数：19 · 研究领域：Bacteriophages and microbial interactions、Orthopedic Infections and Treatments、Monoclonal and Polyclonal Antibodies Research

• BJI challenges: orthopaedic infections are challenging due to antibiotic resistance and biofilms. • Phage therapy's Promise: it's a non-antibiotic solution with unique abilities to combat infection challenges effectively. • Gram-negative focus: phage therapy is emerging as a strategy against antibiotic-resistant Gram-negative infections in orthopaedics. • Efficacy and challenges: bacteriophages are promising against infections, yet challenges like a narrow host range underscore the need for standardization and collaboration in orthopaedic treatments. Bone and joint infections (BJI) pose formidable challenges in orthopaedics due to antibiotic resistance and the complexities of biofilm, complicating treatment. This comprehensive exploration addresses the intricate challenges posed by BJI and highlights the significant role of phage therapy as a non-antibiotic strategy. BJI, which encompass prosthetic joint infections, osteomyelitis, and purulent arthritis, are exacerbated by biofilm formation on bone and implant surfaces, hindering treatment efficacy. Gram-negative bacterial infections, characterized by elevated antibiotic resistance, further contribute to the clinical challenge. Amidst this therapeutic challenge, phage therapy emerges as a potential strategy, showing unique characteristics such as strict host specificity and biofilm disruption capabilities. The review unveils the dynamics of phages, including their origins, lifecycle outcomes, and genomic characteristics. An...