Multifunctional and immunoregulatory microenvironment-responsive hydrogel for whole course management of infected diabetic wounds

作者：Zhenyu Luo, Xiaoxue Fu, Hua Jiang, Weikun Meng, Shue Jin, Yongrui Cai, Ze Du, Ping Song, An-Jing Chen, Li Li, Peifang Li, Jiali Chen, Weinan Zeng, Zongke Zhou · 发表于：Chemical Engineering Journal · 年份：2024 · DOI：10.1016/j.cej.2024.154924 · 被引用次数：12 · 研究领域：Wound Healing and Treatments、Electrospun Nanofibers in Biomedical Applications、Nerve injury and regeneration

Creating a multifunctional microenvironment-responsive ATAN-Met hydrogel system promotes infective diabetic wound healing by enhancing re-epithelialization, neurovascular-hair follicles regeneration, antibacterial and immunoregulation. • A novel strategy using a microenvironment-responsive ATAN-Met hydrogel system to promote infective diabetic wounds healing. • The hydrogel has impressive self-healing and wearable properties, responding to high Glucose/ROS for drug release. • The system exhibited anti-bacterial, reduced inflammation, promoted nerve regeneration and hair follicle regrowth. • The system activated the Hippo pathway, inhibit the TNF pathway to improve the diabetic wound healing. Infective diabetic wounds can significantly delay healing and pose severe infection risks. The process of infective diabetic wounds healing (DWH) are not only re-epithelialization and angiogenesis but also anti-bacterial, hair follicles regeneration and nerve growth. In this study, a stable dynamic hydrogel system was formulated by incorporating dynamic borate easter bond and carbon–carbon double bond, which based on tannic acid (TA) − acrylic phenyl boric acid (APBA) and acrylamide (AM). Subsequently, a hydrogel (ATAN-Met) was obtained by modifying the antibacterial ammonium cationic (N + ) and loading metformin (Met). This system demonstrated impressive wet adhesion, self-healing, wearable and peelable properties, responding to glucose/reactive oxygen species (ROS) for drug release. In ...