Association of Low- and No-Calorie Sweetened Beverages as a Replacement for Sugar-Sweetened Beverages With Body Weight and Cardiometabolic Risk: A Systematic Review and Meta-analysis

作者：Néma McGlynn, Tauseef A Khan, Lily Wang, Roselyn Zhang, Laura Chiavaroli, Fei Au‐Yeung, Jenn Lee, Jarvis C. Noronha, Elena M. Comelli, Sonia Blanco Mejía, Amna Ahmed, Vasanti Malik, James O. Hill, Lawrence A. Leiter, Arnav Agarwal, Per Bendix Jeppesen, Dario Rahelić, Hana Kahleová, Jordi Salas‐Salvadó, Cyril W.C. Kendall, John L Sievenpiper · 年份：2024 · DOI：10.32920/26767786 · 被引用次数：9 · 研究领域：Diet, Metabolism, and Disease、Nutrition, Genetics, and Disease、Biochemical Analysis and Sensing Techniques

<div><strong>Importance:</strong> There are concerns that low- and no-calorie sweetened beverages (LNCSBs) do not have established benefits, with major dietary guidelines recommending the use of water and not LNCSBs to replace sugar-sweetened beverages (SSBs). Whether LNCSB as a substitute can yield similar improvements in cardiometabolic risk factors vs water in their intended substitution for SSBs is unclear.</div> <div><strong>Objective:</strong> To assess the association of LNCSBs (using 3 prespecified substitutions of LNCSBs for SSBs, water for SSBs, and LNCSBs for water) with body weight and cardiometabolic risk factors in adults with and without diabetes.</div> <div><strong>Data sources:</strong> Medline, Embase, and the Cochrane Central Register of Controlled Trials were searched from inception through December 26, 2021.</div> <div><strong>Study selection:</strong> Randomized clinical trials (RCTs) with at least 2 weeks of interventions comparing LNCSBs, SSBs, and/or water were included.</div> <div><strong>Data extraction and synthesis:</strong> Data were extracted and risk of bias was assessed by 2 independent reviewers. A network meta-analysis was performed with data expressed as mean difference (MD) or standardized mean difference (SMD) with 95% CIs. The GRADE (Grading of Recommendations Assessment, Development and Evaluation) system was used to assess ...