A Transdiagnostic Network Analysis of Childhood Trauma and Psychopathology

作者：Yi‐hang Huang, Chao Liu, Jianbiao Zhang, Shuai‐biao Li, Lingling Wang, Hui‐xin Hu, Yuan Cai, Zhenhua Zhu, Min‐yi Chu, Yi Wang, Qinyu Lv, Simon S. Y. Lui, Zhenghui Yi, Li Hui, Raymond C. K. Chan · 发表于：Schizophrenia Bulletin · 年份：2024 · DOI：10.1093/schbul/sbae137 · 被引用次数：12 · 研究领域：Mental Health Research Topics、Personality Disorders and Psychopathology、Schizophrenia research and treatment

BACKGROUND AND HYPOTHESIS: Psychiatric comorbidities suggest that symptoms overlap across different diagnoses; the transdiagnostic network approach is valuable for studying psychopathology. Childhood trauma is a common transdiagnostic risk factor for psychiatric disorders, but the complex relationship between childhood trauma and psychopathology has seldom been investigated using a large cross-sectional transdiagnostic sample. STUDY DESIGN: This study recruited 869 patients with different diagnoses, including 418 schizophrenia, 215 bipolar disorder, and 236 major depressive disorder. Participants completed psychiatric interviews and self-report questionnaires. We constructed dimension- and item-level Least Absolute Shrinkage and Selection Operator-based (LASSO) networks to explore the relationship between childhood trauma, psychopathology, and duration of illness. Moreover, we constructed directed acyclic graphs (DAGs) to tentatively clarify the potential directions of associations among these variables. Network Comparison Tests (NCTs) were conducted for different diagnostic groups and gender-stratified groups. STUDY RESULTS: The transdiagnostic LASSO networks showed that different types of childhood trauma exerted distinct impacts on various psychopathological dimensions. Emotional abuse was linked to depressive symptoms, physical abuse to excited symptoms, sexual abuse to positive and disorganized symptoms, emotional neglect to depressive symptoms and motivation and pleasur...