Blood-based biomarkers of neuronal and glial injury in active major neuropsychiatric systemic lupus erythematosus

作者：Ryan Kammeyer, Kimberly Chapman, Anna Furniss, Elena W.Y. Hsieh, Robert C. Fuhlbrigge, Ekemini A. Ogbu, Susan A. Boackle, JoAnn Zell, Kavita V. Nair, Tyler L. Borko, Jennifer C. Cooper, Jeffrey L. Bennett, Amanda L. Piquet · 发表于：Lupus · 年份：2024 · DOI：10.1177/09612033241272961 · 被引用次数：14 · 研究领域：Systemic Lupus Erythematosus Research、Multiple Sclerosis Research Studies、Systemic Sclerosis and Related Diseases

Background Neuropsychiatric systemic lupus erythematosus (NPSLE) is a poorly understood and heterogeneous manifestation of SLE. Common major NPSLE syndromes include strokes, seizures, myelitis, and aseptic meningitis. Easily obtainable biomarkers are needed to assist in early diagnosis and improve outcomes for NPSLE. A frequent end-result of major syndromes is neuronal or glial injury. Blood-based neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) have been utilized as markers for monitoring disease activity and/or severity in other neurodegenerative and neuroinflammatory diseases; however, they have not been evaluated in active major NPSLE. Methods This was a case-control study. We enrolled patients aged 12-60 years with active major NPSLE, SLE without active major NPSLE, and healthy controls. Active NPSLE was defined as being <6 months from last new or worsening neuropsychiatric symptom. Demographics, clinical data, and serum or plasma biosamples were collected. Results Thirteen patients with active major NPSLE, 13 age/sex/kidney function matched SLE controls without active major NPSLE, and 13 age/sex matched healthy controls (mean ages 26.8, 27.3, 26.6 years) were included. 92% of each group were female. Major syndromes included stroke (5), autonomic disorder (3), demyelinating disease (2), aseptic meningitis (2), sensorimotor polyneuropathy (2), cranial neuropathy (1), seizures (1), and myelopathy (2). Mean (standard deviation) blood NfL and GFAP were...