Effect of hydrocolloid‐nitric oxide wound dressings on wound healing in dogs

作者：Jenniffer M. Rodriguez‐Diaz, Mandy L. Wallace, Sarah A. Emond, Danielle McNabney, Katie M. Hodges, Elizabeth W. Howerth · 发表于：Veterinary Surgery · 年份：2024 · DOI：10.1111/vsu.14149 · 被引用次数：5 · 研究领域：Wound Healing and Treatments、Nitric Oxide and Endothelin Effects、Surgical Sutures and Adhesives

Abstract Objective To determine the rates of wound healing in surgically created wounds between nitric oxide releasing wound dressings and control wound dressings. Study design Prospective, controlled, randomized experimental study. Animals Purpose‐bred, adult, male Beagles ( n = 6). Methods Four 2 × 2 cm wounds were surgically created on the trunk of each dog with each wound randomized to treatment with a nitric oxide wound pad (NP), nitric oxide wound gel (NG), plain hydrocolloid wound dressing (HC), or Telfa pad (T). Wound images were taken daily for 8 days then every other day until day 21 with images masked and randomized for evaluation. Total wound area, contraction percentage, and days until granulation were calculated. Results Time to first appearance of granulation tissue was significantly shorter for NP (3.2 days) than for NG (4 days; p = .023), HC (4.5 days; p = .001), and T (5.2 days; p < .0001). There were significant differences in total wound area and contraction percentage between sites and treatments ( p < .001). Total wound area for NG was lower than treatment T (0.7 ± 0.1 cm 3 ; p < .001), HC (0.9 ± 0.1 cm 3 , p < .001), and NP (0.6 ± 0.1 cm 3 , p < .001). Conclusion Use of a nitric oxide wound dressing resulted in faster wound healing as evidenced by lower total wound area and higher contraction in the NG group and faster time to granulation tissue development in the NP group. Clinical significance Nitric oxide wound dressings are innovative...