Insights into the cardiovascular benefits of taurine: a systematic review and meta-analysis

作者：Chih-Chen Tzang, Wei‐Chen Lin, Long‐Huei Lin, Ting‐Yu Lin, Ke‐Vin Chang, Wei‐Ting Wu, Levent Özçakar · 发表于：Nutrition Journal · 年份：2024 · DOI：10.1186/s12937-024-00995-5 · 被引用次数：25 · 研究领域：Aldose Reductase and Taurine、Biochemical Acid Research Studies、Peroxisome Proliferator-Activated Receptors

BACKGROUND: Cardiovascular disease (CVD) remains the foremost cause of mortality globally. Taurine, an amino acid, holds promise for cardiovascular health through mechanisms such as calcium regulation, blood pressure reduction, and antioxidant and anti-inflammatory effects. Despite these potential benefits, previous studies have yielded inconsistent results. This meta-analysis of randomized controlled trials (RCTs) aims to evaluate the existing evidence on the quantitative effects of taurine on hemodynamic parameters and cardiac function grading, which are indicative of overall cardiovascular health and performance. METHODS: We conducted an electronic search across multiple databases, including Embase, PubMed, Web of Science, Cochrane CENTRAL, and ClinicalTrials.gov, from their inception to January 2, 2024. Our analysis focused on key cardiovascular outcomes, such as heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular ejection fraction (LVEF), and New York Heart Association (NYHA) Functional Classification. Meta-regression was applied to explore dose-dependent relationships based on the total taurine dose administered during the treatment period. A subgroup analysis, stratified according to the baseline disease status of patients, was also conducted. RESULTS: The analysis included a pooled sample of 808 participants from 20 randomized controlled trials. Taurine demonstrated a significant reduction in HR (weighted mean difference [W...