Deuterium Metabolic Imaging (DMI) for 3D Mapping of Glucose Metabolism in Humans with Central Nervous System Lesions at 3T

作者：Philip Adamson, Keshav Datta, Ron Watkins, Lawrence D. Recht, Ralph E. Hurd, Daniel M. Spielman · 发表于：Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition · 年份：2024 · DOI：10.58530/2023/0009 · 被引用次数：6 · 研究领域：Advanced MRI Techniques and Applications、Atomic and Subatomic Physics Research、Advanced NMR Techniques and Applications

DMI is an emerging modality for investigating glucose metabolism in vivo with application for assessing the Warburg effect in tumors. Although high-field systems, e.g. 7T, provide maximal signal-to-noise ratio (SNR), implementation on widely available 3T scanners could have immediate clinical impact. Here we explore the potential of 3T DMI using a birdcage 2H RF coil in two healthy volunteers and three patients with CNS lesions of varying pathology. Results from these experiments demonstrate the potential to examine the Warburg effect in CNS lesions with DMI at 3T and provide critical data needed to explore DMI SNR and spatial resolution limits.