Expert consensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children

作者：Yingshuo Wang, Yunlian Zhou, Guannan Bai, Shuxian Li, Dan Xu, Lina Chen, Xing Chen, Xiaoyan Dong, Hong-Min Fu, Zhou Fu, Chuangli Hao, Jianguo Hong, Enmei Liu, Hanmin Liu, Xiaoxia Lü, Zhengxiu Luo, Lan-Fang Tang, Man Tian, Yong Yin, Xiaobo Zhang, Jianhua Zhang, Hailin Zhang, Deyu Zhao, Shunying Zhao, Guo-Hong Zhu, Yingxue Zou, Quan Lu, Zizai Zhang, Zhi-Min Chen · 发表于：World Journal of Pediatrics · 年份：2024 · DOI：10.1007/s12519-024-00831-0 · 被引用次数：127 · 研究领域：Pneumonia and Respiratory Infections、Bacterial Infections and Vaccines、Antibiotics Pharmacokinetics and Efficacy

BACKGROUND: Mycoplasma pneumoniae (M. pneumoniae) is a significant contributor to community-acquired pneumonia among children. Since 1968, when a strain of M. pneumoniae resistant to macrolide antibiotics was initially reported in Japan, macrolide-resistant M. pneumoniae (MRMP) has been documented in many countries worldwide, with varying incidence rates. MRMP infections lead to a poor response to macrolide antibiotics, frequently resulting in prolonged fever, extended antibiotic treatment, increased hospitalization, intensive care unit admissions, and a significantly higher proportion of patients receiving glucocorticoids or second-line antibiotics. Since 2000, the global incidence of MRMP has gradually increased, especially in East Asia, which has posed a serious challenge to the treatment of M. pneumoniae infections in children and attracted widespread attention from pediatricians. However, there is still no global consensus on the diagnosis and treatment of MRMP in children. METHODS: We organized 29 Chinese experts majoring in pediatric pulmonology and epidemiology to write the world's first consensus on the diagnosis and treatment of pediatric MRMP pneumonia, based on evidence collection. The evidence searches and reviews were conducted using electronic databases, including PubMed, Embase, Web of Science, CNKI, Medline, and the Cochrane Library. We used variations in terms for "macrolide-resistant", "Mycoplasma pneumoniae", "MP", "M. pneumoniae", "pneumonia", "MRMP", "lo...