Transcranial Temporal Interference Stimulation of the Right Globus Pallidus in Parkinson's Disease

作者：Chenhao Yang, Yongxin Xu, Xiaofan Feng, Bowen Wang, Yichao Du, Kexin Wang, Jiaojiao Lü, Lingyan Huang, Zhenyu Qian, Zhen Wang, Nan Chen, Junhong Zhou, Chencheng Zhang, Yu Liu · 发表于：Movement Disorders · 年份：2024 · DOI：10.1002/mds.29967 · 被引用次数：58 · 研究领域：Neurological disorders and treatments、Transcranial Magnetic Stimulation Studies、Pain Management and Treatment

BACKGROUND: Invasive deep brain stimulation (DBS) has been shown to be effective in treating patients with Parkinson's disease (PD), yet its clinical use is limited to patients at the advanced stage of the disease. Transcranial temporal interference stimulation (tTIS) may be a novel nonneurosurgical and safer alternative, yet its therapeutic potential remains unexplored. OBJECTIVE: This pilot study aims to examine the feasibility and safety of tTIS targeting the right globus pallidus internus (GPi) for motor symptoms in patients with PD. METHODS: Twelve participants with mild PD completed this randomized, double-blind, and sham-controlled experiment. Each of them received either 20-minute or sham tTIS of the right GPi. Before and immediately after the stimulation, participants completed the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS-III) in the "medication-on" state to assess the motor symptoms. The blinding efficacy and side effects were also assessed. RESULTS: tTIS was well tolerated by participants, with only mild, transient adverse effects reported. tTIS significantly reduced MDS-UPDRS-III scores by 6.64 points (14.7%), particularly in bradykinesia (23.5%) and tremor (15.3%). The left side showed more significant alleviation in motor symptoms, particularly bradykinesia, compared to the right side. Participants with severer bradykinesia and tremor before stimulation experienced greater improvement after tTIS. CONCLUSION: This pilot study ...