Research Progress of Metal–Organic Frameworks as Drug Delivery Systems

作者：Chenxin Liu, Chaoying Tian, Jialing Guo, Xiaodi Zhang, Ligang Wu, Ling Zhu, Bin Du · 发表于：ACS Applied Materials & Interfaces · 年份：2024 · DOI：10.1021/acsami.4c09536 · 被引用次数：42 · 研究领域：Metal-Organic Frameworks: Synthesis and Applications、Dendrimers and Hyperbranched Polymers、Advanced Nanomaterials in Catalysis

Metal-organic frameworks (MOFs) are composite crystalline materials created through the coordination of metal ions and organic ligands. MOFs have attracted extensive attention in the biomedical field based on the advantages of internal porosity, customizable porosity, and facile surface modification. This review examines the utilization of MOFs in drug delivery systems, focusing on the research progress from the aspects of coloading drug systems, intelligent responsive carriers, biological macromolecule stabilizers, self-driving micro/nanomotors, and multifunctional living carriers. In addition, the current challenges the research faces are also discussed. The review aims to provide a reference for the further application of MOFs as advanced drug delivery systems.