Differentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort

作者：Kristine M. Erlandson, Linda N. Geng, Caitlin Selvaggi, Tanayott Thaweethai, Peter Chen, Nathan Erdmann, Jason D. Goldman, Timothy J. Henrich, Mady Hornig, Elizabeth W. Karlson, Stuart D. Katz, Chun Kim, Sushma K. Cribbs, Adeyinka O. Laiyemo, Rebecca Letts, Janet Lin, Jai Marathe, Sairam Parthasarathy, Thomas F. Patterson, Brittany D. Taylor, Elizabeth R. Duffy, Monika Haack, Boris Jülg, Gabrielle Maranga, Carla Hernandez, Nora G. Singer, Jenny E. Han, Priscilla Pemu, Hassan Brim, Hassan Ashktorab, Alexander W. Charney, Juan P. Wisnivesky, Jenny J. Lin, Helen Y. Chu, Minjoung Go, Upinder Singh, Emily B. Levitan, Paul Goepfert, Janko Ž. Nikolich, Harvey Hsu, Michael J. Peluso, J. Daniel Kelly, Megumi J. Okumura, Valerie J. Flaherman, John G. Quigley, Jerry A. Krishnan, Mary Beth Scholand, Rachel Hess, Torri D. Metz, Maged M. Costantine, Dwight J. Rouse, Barbara S. Taylor, Mark P. Goldberg, Gailen D. Marshall, Jeremy P. Wood, David E. Warren, Leora Horwitz, Andrea S. Foulkes, Grace A. McComsey, RECOVER-Adult Cohort, Jeffrey Burns, Serena Spudich, L. Charles Bailey, Mine Cicek, Melissa Cortez, Felicia Davis Blakley, Andrea S. Foulkes, David C. Goff, Stuart D. Katz, Jessica Lasky‐Su, Torri Metz, Lisa T. Newman, Igho Ofotokun, Sudha Seshadri, Melissa Stockwell, James R. Stone, Brittany D. Taylor, PJ Utz, Neely Williams, Hassan Ashktorab, Jeannette M. Beasley, Karyn Bishof, Yu Chen, Lori B. Chibnik, Dani Dumitriu, Jennifer Frontera, Paul Goepfert, Sylvie Goldman, Stephen M. Hewitt, Matthew J. Huentelman, Barbara I. Karp, Jerry A. Krishnan, Sarah Laury, Bruce D. Levy, Janko Nikolich-Zugich, Margaret J. Ochocinska, Laura Pace, Alice Perlowski, William Reeves, Juan C. Salazar, Lumy Sawaki-Adams, Sujata Thawani, Hannah Valantine, Drenna Waldrop, Dana Wolff-Hughes, Marta Cerda, Victor H. Clash, Felicia Davis Blakley, Brittany Taylor, Mike Zissis, Teresa Akintonwa, Frank Blancero, Heather-Elizabeth Brown, Megan Carmilani, Debra Copeland, Yvonka Hall, kevin kondo, Lydia Lerma, Jacqui Lindsay, Heather Marti, Christine Maughan, Tony Minor, Hyatt Vincent, Andra L. Blomkalns, David Warburton, Ingrid V. Bassett, Rebecca G. Clifton, Hannah Davis, Nathan Erdmann, Valerie Flaherman, Margot Gage Witvliet, Mark P. Goldberg, Zoe Guan, Jonathan D. Klein, Gregory Laynor, Thomas F. Martínez, Rebecca McGrath, Sairam Parthasarathy, Priscilla Pemu, Erika B. Rosenzweig, Jacqueline Rutter, Hugh Auchincloss, Diana W. Bianchi, Jennifer Moss Breen, Patti Brennan, Jeffrey Burns, Nakela L. Cook, Felicia Davis Blakley, Betty Diamond, Mitchell S.V. Elkind, Lee Fleisher, Andrea Foulkes, Gary H. Gibbons, Laurie Gutmann, Michael F. Iademarco, Stuart Katz, Walter J. Koroshetz, Eldrin F. Lewis, Peter Marks, Hilary D. Marston, Mitchell G. Miglis, Lisa A. Newman, Tracy L. Nolen, Carlos A. Pardo, Amy Patterson, Samuel F. Posner, Wendy S. Post, Serena Spudich, Clinton B. Wright, Heather E. Yates, Kanecia O. Zimmerman, Gabriel Anaya, Audie A. Atienza, L. Charles Bailey, R. Graham Barr, Lisa G. Berdan, Andra L. Blomkalns, Melissa L. Bondy, Hassan Brim, Jeffrey Burns, Alexander W. Charney, Benjamin K. Chen, Mine Cicek, John F. Crary, Dawood Darbar, Kathi Diviak, Ray F. Ebert, Jamie Elifritz, Robert L. Ferrer, Josh Fessel, Aloke V. Finn, Thomas J. Flotte, Paul Fontelo, Andrea Foulkes, Emily J. Gallagher, Maria Gennaro, Mary Groesch, Rachel S. Gross, Melissa Haendel, James R. Heath, Rachel Hess, Stephen M. Hewitt, Sally Hodder, Carol R. Horowitz, Leora Horwitz, Vanessa L. Jacoby, Sarah E. Jolley, Suzanne E. Judd, Bill G. Kapogiannis, Elizabeth Karlson, Barbara I. Karp, Stuart Katz, Rainu Kaushal, Lawrence C. Kleinman, Jerry A. Krishnan, Sweta Ladwa, Craig Lefebvre, Lei Lei, Emily B. Levitan, Bruce D. Levy, Daniel Liu, Jeffrey N. Martin, Grace A. McComsey, Robin J. Mermelstein, Torri Metz, Lucio Miele, Sindhu Mohandas, Janet Mullington, Shawn Murphy, Jane W. Newburger, Lisa Newman, Margaret J. Ochocinska, Igho Ofotokun, Princess U. Ogbogu, Michelle Olive, Sairam Parthasarathy, Amy Patterson, Thomas Patterson, Gail D. Pearson, Priscilla Pemu, J. Zachary Porterfield, Antonello Punturieri, R. Ross Reichard, Jane E.B. Reusch, Kyung E. Rhee, Kathleen Rodgers, Juan C. Salazar, Amy Salisbury, Lumy Sawaki-Adams, Lisa Schwartz-Longacre, Sudha Seshadri, Howard D. Sesso, Eyal Shemesh, Allan C. Shipp, Upinder Singh, Jessica Snowden, Serena Spudich, Melissa Stockwell, James R. Stone, Jun Sun, Mehul S. Suthar, David M. Systrom, Brittany D. Taylor, Stephen N. Thibodeau, Andrea Troxel, PJ Utz, Tiffany Walker, David Warburton, Gail Weinmann, Neely Williams, Dana Wolff-Hughes, John C. Wood, Khamal Anglin, Emilia Bagiella, Ryan C. Branski, Rodica Pop‐Busui, Marissa Diggs, Vivian S. Gainer, Sunanda Gaur, Linda N. Geng, Sarah E. Jolley, Sarah Laury, Jai Marathe, Lisa McCorkell, Jarrod Mosier, Binita Shah, Dimpy P. Shah, Tiffany Walker, Peter Whitesell, Natasha Altman, Tellen D. Bennett, Soham Dasgupta, Marissa Edminston, Tyler Gustafson, Francois Haddad, Jennifer Hossain, Priscilla Hsue, Pavitra Kotini-Shah, Krishnan Sankaran, Anu Lala-Trindade, Simon Lee, Alem Mehari, Patricio Millar Vernetti, André L. Moreira, Anoop M. Nambiar, Robert F. Padera, Gail D. Pearson, Dhaval Raval, Franz Rischard, Erika B. Rosenzweig, Barbara A. Sampson, Frank C. Sciurba, Jackie Szmuszkovicz, Julie M. Thompson, Dongngan T. Truong, Viola Vaccarino, George Washko, John C. Wood, Hector Bonilla, Christine A. Capone, Sekai Chideya-Chihota, Dane B. Cook, Monica Gutierrez, Rohan Hazra, Leonard A. Jason, Phillip Joseph, Dan Kelly, Joyce Lee-Ianotti, Vincent C. Marconi, Joshua D. Milner, Benjamin H. Natelson, Lisa O’Brien, Carlos R. Oliveira, J. Zachary Porterfield, Claire Quiner, Zaki Sherif, Nora Singer, Inderjit Singh, David M. Systrom, Chen Sabrina Tan, Emily Taylor, Vanessa Thornburg, Suzanne D. Vernon, Quinn Barnette, Frank Blanceró, Mine Cicek, Lauren A. Decker, Jasmin Divers, Ray F. Ebert, Tonya Farris, Valerie Flaherman, Thomas J. Flotte, Andrea Foulkes, Rachel Gross, Sally Hodder, Leora I. Horwitz, Elizabeth Karlson, Stuart D. Katz, Craig Lefebvre, Lei Lei, Shawn N. Murphy, Lisa Newman, Michelle Olive, Tony Punturieri, Lisa Schwartz Longacre, Upinder Singh, Stephen N. Thibodeau, Andrea B. Troxel, David Warburton, Jordan C. Weyer, Brett R. Anderson, Sujata Bardhan, Leah Castro-Baucom, Deena J. Chisolm, Alicia Chung, Claudia Corchado, Casey L. Daniel, Walter Dehority, Gniesha Y. Dinwiddie, Candace H. Feldman, Lisa G. Rosas, Carol R. Horowitz, Janice John, Gelise L. Thomas, Keila N. Lopez, Karen Lutrick, Carina Marquez, Shelly McDonald Pinkett, Lidia Regino, Kim F. Rhoads, Sarah Stewart de Ramirez, Joel Tsevat, Carlos Valencia, Nita Vangeepuram, Anita Walden, Zanthia Wiley, Neely Williams, H. Shonna Yin, Galit Alter, Hulya Bukulmez, Chao Jiang, Ai‐ris Y. Collier, Karen H. Costenbader, Betty Diamond, Rao L. Divi, Nahed El Kassar, Nathan Erdmann, F. Eun‐Hyung Lee, Alicia Gaffney, Sacha Gnjatic, Jason Goldman, Jim F. Heath, Jennifer Hossain, Hye-Sook Kim, Ellen Kraig, Timothy Lewis, Joy Liu, Gabrielle Maranga, Aprajita Mattoo, Joshua D. Milner, Sindhu Mohandas, Janko Nikolich-Zugich, Princess U. Ogbogu, Michael J. Peluso, Bellur S. Prabhakar, Jay S. Raval, Mark Sullivan, Paul J. Thuluvath, PJ Utz, Sidney W. Whiteheart, Nina Caplin, Dawood Darbar, Katie Fain, Thomas J. Flotte, David S. Goldstein, Meredith Hay, Ellie Hirshberg, Barbara I. Karp, Dean L. Kellogg, Rebecca Letts, Meisha Mandal, Janet Mullington, Michael Portman, David Putrino, Jacqueline Rutter, Lumy Sawaki-Adams, Joel D. Trinity, John C. Wood, Roham T. Zamanian, Judy Aberg, Farshad Aduli, Andrew M. Atz, Lawrence Baizer, Hector Bonilla, Patricia Ceger, Maged M. Costantine, Amelia N. Deitchman, Kelly K. Filipski, Jeffrey Fine, Liza Fisher, Paul Fontelo, Vilma Gabbay, Jason D. Goldman, Mi Hillefors, Verna Holmes, Arthur Y. Kim, Grace McComsey, Grégory Mertz, Sindhu Mohandas, Margaret Ochinska, Thomas F. Patterson, Michael J. Peluso, John G. Quigley, Kathleen Rodgers, Nadine Rouphael, Gwen Shaw, Bob Tamburro, David Williams, William T. Zempsky, Christian Bime, Steven B. Bradfute, Benjamin K. Chen, Tom Connors, Krista Coombs, Glenn I. Fishman, Maria Gennaro, Christian R. Gómez, Timothy J. Henrich, David Hines, Prasanna Jagganathan, Judith A. James, Kevin Jordan, Boris Juelg, Christina Kim, Jia Lu, Sindhu Mohandas, Michael Portman, Erin Burke Quinlan, Brian Reeves, Jalees Rehman, Ignacio Sanz, Zaki Sherif, Guofei Zhou, Irina A. Buhimschi, Floyd H. Chilton, Ralph A. DeFronzo, Emily J. Gallagher, Jennifer Hossain, Wendy Jefferson, Mandana Khalili, Angesom Kibreab, Tracey McLaughlin, Nandini Nair, Venkat Narayan, Elizabeth Phillips Lorenzo, Jane E.B. Reusch, Ivonne Hernandez Schulman, Aasma Shaukat, Deborah J. Wexler, Jonah Zaretsky, William Alexander, Leyna Aragon, Ami S. Bhatt, Hassan Brim, Shari B. Brosnahan, John M. Coffin, Adolfo García‐Sastre, Maria Laura Gennaro, Joerg Graf, Timothy Henrich, Nahed Ismail, Paul Keim, Hye-Sook Kim, Jeanne Marrazzo, Rebecca McGrath, Sindhu Mohandas, Christopher Montgomery, Radu Postelincu, Ryan T. Ranallo, Kentner Singleton, Adam M. Spivak, Mehul S. Suthar, Mary Thomas, Guangming Zhong, John Andrefsky, Bryan Bander, J. Douglas Bremner, Michael D. Carrithers, Melissa Cortez, Richard Gallagher, Joanna Hellmuth, Tammy Kershner, Mansoor Malik, Shawn Murphy, Ganesh Murthy, Sharon O’Neil, Lisa Prentiss, Caitlin Rollins, Jonathan Rosand, Scott J. Russo, Amy Salisbury, Alan C. Seifert, Sudha Seshadri, Eyal Shemesh, Wendy G. Silver, Naomi M. Simon, Leanne E. Williams, Masanori Aikawa, Hassan Ashktorab, Noam D. Beckmann, Jasmin Divers, Mike Enger, Stephen Erickson, Joaquı́n M. Espinosa, Xiaowu Gai, Stephen M. Hewitt, Benjamin D. Horne, Paul Keim, Jessica Lasky‐Su, Cheryl L. Maier, Meisha Mandal, Lucio Miele, Emmanuel F. Mongodin, Lauren Nichols, Nadia R. Roan, Mark W. Russell, George R. Saade, Kumar Sharma, Stephanie Shiau, Jun Sun, Stephen N. Thibodeau, Sam Yang, Nina Blachman, Natalie Boutin, Phoebe Burton, Marina Catallozzi, Cheryl R. Clark, Beth Dworetzky, Belinda Edwards, Robert L. Ferrer, Catherine Freeland, Beatrice Huang, Suzanne E. Judd, Sarah Laury, Hugh Musick, Divya Pathak, Kristen Pogreba-Brown, Hengameh Raissy, Lynne Richardson, Russell L. Rothman, Laura Wagner, Ann Wallace, Stephanie Archer, Paul Barach, Melissa L. Bondy, Víctor M. Castro, Mine Cicek, Joanne W. Elena, Kacey C. Ernst, Josh Fessel, Daniel Fort, Brian Hendricks, Bertha Hidalgo, Cory Hussain, Carmen R. Isasi, Dan Kelly, Adeyinka O. Laiyemo, Margaret Lanca, Juan Lewis, Beth Linas, Heidi T. May, Kimberly E. McHugh, Naoko Muramatsu, Girish N. Nadkarni, Susan Nance, Kian Nguyen, Priscilla Pemu, Lisa Postow, Suchitra Rao, Dimpy P. Shah, Sidd Shenoy, Kendall Tosco, Dana L. Wolff‐Hughes, C. M. Bailey, James Chan, Nancy Chang, Mine S. Cicek, Hannah Davis, Kathi Diviak, Daniel Fort, Jennifer C. Gander, Janos Hajagos, Kellie L. Hawkins, Md Shahidul Islam, Dan Kelly, Tammy Kershner, Patricia Kovatch, Simon Li, Daniel Liu, Holden T. Maecker, F Mahmood, Emily Pfaff, Anisha Sekar, Zaki A. Sherif, Vignesh Subbian, M. Thakrar, Anand Viswanathan, Jennifer L. Wheeler, Meredith Zozus, Yvette Burgos, Chris Chute, Elizabeth W. Karlson, Barbara I. Karp, Emily B. Levitan, Gabrielle Maranga, Gailen D. Marshall, Jeffrey N. Martin, Robin Mermelstein, Torri D. Metz, Igho Ofotokun, Sairam Parthasarathy, Lumy Sawaki-Adams, Mary Beth Scholand, Howard D. Sesso, Nora G. Singer, Lauren E. Stiles, Barbara S. Taylor, Juan P. Wisnivesky, Lisa T. Newman, Julie Abella, Quinn Barnette, Christine A. Bevc, Jennifer Beverly, Julie Croxford, Tonya Farris, Sean Hanlon, David Hines, Vicki Johnson‐Lawrence, Craig Lefebvre, Beth Linas, Bryan Luukinen, Meisha Mandal, Nikki J. McKoy, Demian Pasquarelli, Claire Quiner, Rita Sembajwe, Vanessa Thornburg, Kendall Tosco, Hannah Wright, Rachel S. Gross, Judith S. Hochman, Leora I. Horwitz, Stuart D. Katz, Andrea B. Troxel, Lenard A. Adler, Precious Akinbo, Ramona Almenana, Malate Aschalew, L. Balick, Ola Bello, Sultana Bhuiyan, Nina Blachman, Ryan C. Branski, Jasmine Briscoe, Shari B. Brosnahan, Elliott Bueler, Yvette Burgos, Nina Caplin, Domonique N. Chaplin, Yu Chen, Cheng Shen, Peter Choe, Jess Choi, Richard Church, Stanley E. Cobos, Nakia Croft, Angelique Cruz Irving, Phoebe Del Boccio, Iván Díaz, Jasmin Divers, Vishal Doshi, Benard P. Dreyer, Samantha Ebel, Shari Esquenazi‐Karonika, Arline Faustin, Elias Febres, Jeffrey Fine, Sandra Fink, Catherine Freeland, Jennifer Frontera, Richard Gallagher, Alejandra González‐Duarte, Rachel S. Gross, Denise Hasson, Sophia Hill, Judith S. Hochman, Leora Horwitz, Jennifer Hossain, Md Shahidul Islam, Christina Saint Jean, Stephen B. Johnson, Neha Kansal, Stuart Katz, Rachel Kenney, Tammy Kershner, Deepshikha Kewlani, Judy Kwak, Michelle F. Lamendola-Essel, Sarah Laury, Gregory Laynor, Lei Lei, Terry Leon, Janelle Linton, Max Logan, Nadia Malik, Lia Mamistvalova, Hannah Mandel, Gabrielle Maranga, Aprajita Mattoo, Tony Mei, Alan L. Mendelsohn, Emmanuelle Mercier, Patricio Millar Vernetti, Marc Miller, Maika Mitchell, André L. Moreira, Praveen C. Mudumbi, Erica R. Nahin, Nandini Nair, Joseph Nekulak, Kellie Owens, Brendan Parent, Nandan Patibandla, Peter K. Petrov, Radu Postelnicu, Francesca Pratt, Isabelle Randall, Priyatha Rao, Amy Rapkiewicz, John‐Ross Rizzo, Johana Rosas, Chelsea Rose, Christina Saint-Jean, Michelle Santacatterina, Binita Shah, Naomi M. Simon, Aylin Simsir, Miranda Stinson, Wenfei Tang, Vasishta Tatapudi, Sujata Thawani, Mary Thomas, Lorna E. Thorpe, MeeLee Tom, Ethan Treiha, Andrea Troxel, Jennifer Truong, Mmekom Udosen, Carlos Valencia, Jessica Velazquez-Perez, Patricio Millar Vernetti, Crystal Vidal, Anand Viswanathan, Amy Willerford, Natasha Williams, Crystal Wong, Marion J. Wood, Shannon W. Wuller, H. Shonna Yin, Chloe Young, Jonah Zaretsky, Susanna Zavlunova, Andrea S. Foulkes, Elizabeth Karlson, Shawn N. Murphy, Shreya Ahirwar, Shifa Ahmed, Layne L. Ainsworth, Rachel Atchley-Challenner, Paul Avilach, Trisha T. Balan, Nicholas Benik, Barbara Benoit, Marie‐Abèle Bind, William J. Bonaventura, Natalie Boutin, Beverly Brion, Andrew Cagan, Tianrun Cai, Tingyi Cao, Víctor M. Castro, Xander R. Cerretani, James Chan, Simon Chang, David Cheng, Lori B. Chibnik, Mark Ciriello, Karen H. Costenbader, Dimitar Dimitrov, Hossein Estiri, Maria Fayad, Candace H. Feldman, Vivian S. Gainer, Bhaswati Ghosh, Randy Gollub, Zoe Guan, Alan W. Harris, Karl Helmer, A. R. Hendrix, Ana Holzbach, Weixing Huang, Daniel Kaufman, Diane Keogh, James D. Kerr, Jeffrey G. Klann, Aparna Krishnamoorthy, Jessica Lasky‐Su, Katherine P. Liao, Doug MacFadden, Anupama Maram, Megan W. Martel, Michael Mendis, Reeta Metta, Jonathan Monteiro, Eduardo A. Morales, Richard E. Morse, Marc-Danie Nazaire, Gregory Neils, Amber N. Nguyen, James Norman, Henry Paik, Deepti Pant, Heekyong Park, Dustin J. Rabideau, Harrison T. Reeder, Kathleen Rossi-Roh, L Santacroce, Katherine Schlepphorst, Carolin C. M. Schulte, Caitlin Selvaggi, Daniel J. Shinnick, William M. Simons, Lynn Simpson, Mary L. St. Jean Flanders, Zachary H. Strasser, Mansi R. Thakrar, Tanayott Thaweethai, Madeleine Thorn, Philip Trewett, Dustin Van Fleet, Kavishwar B. Wagholikar, Taowei David Wang, Nich Wattanasin, Griffin M. Weber, Michael Allyn Williams, Ren Zhe Zhang, Mine Cicek, Erik M. Boysen, Nancy Chang, Thomas J. Flotte, Erika Frisch, Gary Welch, Samantha Wirkus, Nicole Zahnle, Natalie Boutin, Shari B. Brosnahan, Xander R. Cerretani, Randy Gollub, Rachel Gross, Karl Helmer, Michelle F. Lamendola-Essel, Gabrielle Maranga, Caroline Moorehouse, Jennifer Payne, Jenny E. Han, Vincent C. Marconi, Ighovwerha Ofotokun, Rachel E. Patzer, Tiffany Walker, Rachael Abraham, Franchesca A. Aguilar, Ghazal Ahmadi-Izad, Dilshad R. Ahmed, Carlos Álvarez, Alicarmen Alvarez, Blake Anderson, Walter D. Asencios, Casey L. Beaty, Brahmchetna Bedi, Jasmine A. Berry, Donchel Boone, Mary Bower, J. Douglas Bremner, Corbin Brent, Ke’Ara Brown-Smith, Rachel Bull, Gustavo Capo, Kelechi Carl-Igwe, Calista Chitadze, Nachi Chukwumerije, Erna Clyburn, Shelby Collins, Julie Costello, Grace Couture, Angel Craft, Xiangqin Cui, Carlos del Rio, Joshua F. Detelich, Cartia Dixon, Jeanne Dow, D.J. Doyle, Jannah Elchommali, Imani Elsey, Nicole Franks, Julia W. Gallini, Evan Gutter, Jess Harding, Lisa Harewood, Liliana Hernández, Carla Holloway, Cynthia Ifejika, Kelechi Igwe, Rijalda Jasarevic, Vidhi Javia, Mykayla Jeter, Yasha Joseph, Monica Juarez, Caitlin M. Kirkpatrick, Athena Koumanelis, Rebecca Kozoman, Shilpa Krishnan, Jordi Lainez, Jose D. Leon, Valerie Lew, Kelly Mahfood, Cheryl L. Maier, Nour Makkaoui, Mara Maroney, Christopher F. Martin, Loice Mbogo, Atuarra McCaslin, J. McIntyre, Abeer Moanna, Miranda Montoya, Elena Martín Morales, Caitlin A. Moran, Calista Murray, Roslin Nelson, Tran Thuy Nguyen, B. Ojoawo, Eileen Osinski, Sofia Oviedo, Yolanda Paredes-Gaitan, Michael Prude, Grace Ramakrishnan, Paulina A. Rebolledo, Marjorie Roberts, Keysha Robinson, Chantrice Rogers, Nadine Rouphael, Charles Searles, Marni Segall, Anand Shah, Renata Michelle Shaw, Ruvina Silva, Cheryl Simpson, Krystal Simpson-Derrell, Talib Sirajud-Deen, Jacob Stroud, Mehul S. Suthar, Cory Sylber, Ashley Sylvera, Tehquin Tanner, Larissa Teunis, Kodasha M. Thomas, Kehmia Titanji, Christopher Toy, Alex Truong, Viola Vaccarino, Kris Varney, Kartavya J. Vyas, Kurt Vyas, Max Walkow, Tamara Wesley, Juton R. Winston, Terra J. Winter, Cherry Wongtrakool, Zanthia Wiley, Arijan Ager, Mary Atha, Rebecca Fineman, Natalie Gray, Ash Grimes, Lauren N. Hewitt, Christopher Huerta, Brandi Johnson, Lana Khalil, Dean J. Kleinhenz, Alexandra Koumanelis, Matthew A. Lee, Kennedy C. Lewis, Matthew Litvack, Bernadine Panganiban, Kazi Mizanur Rahman, Veronica E. Smith, Andre Stringer, Maliya Tolbert, Jessica Traenkner, Kristen Unterberger, Dongli Wang, Erika Wimberly, Priscilla Pemu, Annette Dandy, Carmel Ibeawuchi, Dana Kajan, Brianna Lawrence, Jan Morgan‐Billingslea, Elizabeth I. Ojemakinde, Elizabeth Olorundare, Sushma K. Cribbs, Anyssa G. Francis, Tina P. Hang, Ketteria D. Ingram, Jennifer C. Gander, Robert B. Neuman, Patricia A. Bush, Alex F. Hudgins, Imanii Kolailat, Monica Martinez, Sierra G. Thompson, Bruce D. Levy, Robert F. Padera, Masanori Aikawa, David C. Alsop, Rachel Atchley-Challenner, Lindsey R. Baden, Gaston Baslet, Shamik Bhattacharyya, Renee Brody, Julie E. Buring, R. Cagnina, Long‐Qing Chen, Cheryl R. Clark, Pieter A. Cohen, Andrea M. Collins, Charles A. Czeisler, Sourbha S. Dani, Candace H. Feldman, Sarju Ganatra, Elizabeth Gay, Sheila M. Hegde, Elizabeth W. Karlson, Matcheri S. Keshavan, Marvin A. Konstam, Daniela Lamas, Elizabeth LaSalvia, Jessica Lasky‐Su, Nomi C. Levy‐Carrick, Chun Soo Lim, JoAnn E. Manson, Edward Mercantonio, Murray A. Mittleman, Debra D. Poutsiaka, Susan Redline, Howard D. Sesso, Michelle Siciliano, Isaac H. Solomon, Scott D. Solomon, Jeffrey A. Sparks, Jennifer L. Stevens, Paul Summergrad, David M. Systrom, Andrew J. Taylor, David S. Thaler, David R. Walt, George Washko, Ingrid V. Bassett, Shawn N. Murphy, James R. Stone, George A. Alba, Taing N. Aung, Faye Victoria C. Casimero, Leo C. Ginns, Jennifer S. Haas, Boris D. Juelg, Diane G. Kanjilal, Arthur Y. Kim, Elizabeth B. Klerman, Greg Lewis, Maria Martinez‐Lage, Bisola O. Ojikutu, Roy H. Perlis, Jonathan Rosand, Zachary S. Wallace, Dean Xerras, Danielle Zionts, Janet Mullington, Tamara G. Fong, Monika Haack, Kristine Hauser, Jason H. Maley, Yuri Quintana, Lynn Shaughnessy, Kathryn E. Stephenson, Robert J. Thomas, Robert Carreras‐Torres, Jai Marathe, Elizabeth R. Duffy, Naomi M. Hamburg, Misaki Kobayashi, George O'connor, Fitzgerald M. Shepherd, Charles T. Williams, Haihua Zhang, Janice John, Amberly Ticotsky, Honorine Ward, Deborah Blazey-Martin, Maher Ghamloush, Michael R. Jordan, Laura Kogelman, Nathaniel Erdmann, Emily B. Levitan, Jeanne Marrazzo, Alan Tita, Donna Armstrong, Suzanne E. Judd, Myriam Peralta-Carcelén, Camden L. Hebson, Susan E. Binkley, Kenneth Blackwell, Annalia Causey, Felice Cook, Julio Domingo, Conner Donahue, Maitlyn Eady, Jeffrey C. Edberg, Noah Garcia-McClaney, Melissa Garner, Brandon Gray, Wanda Hall, Cady Hart, Bertha Hidalgo, Kaylen Holtzapfel, Alexis Jinright, Teri Kennedy, Leigh Kirkwood, Megan Maier, Patricia McCormack, Kevin Mitchell, Aoyjai P. Montgomery, Juan P. Pilco, Leigh Powell, Rachael Shevin, Sidney Skipworth, Leah Spurgeon, Gregory Ware, Rosanne Wilson, Dana L. Woodruff, Mark N. Gillespie, Casey L. Daniel, Jamie Hansel, Jing Wu, Jyotsna Fuloria, Paula Datri, Michael Hagensee, Cathryn Leggio, Allen Perkins, Amber Trauth, Siobhan Trotter, Alexander Van Deerlin, Sharon Weiser, Madeline Young, Thomas W. Carton, Lucio Miele, Todd T. Brown, Erica Sutherland, Hassan Ashktorab, Hassan Brim, Adeyinka O. Laiyemo, Zaki A. Sherif, Saima Durrani, Ali Nezamloo, Julius S. Ngwa, Noelle Njoku, Monique P. Gentil, Akbar Solemani, Linda Chang, Paul J. Thuluvath, Mhret Alemu, Jordan Anderson, Mahak Chauhan, Sung Woo Cho, Karli Goodman, Gandi Lanke, Ralph Lebron, Anurag Maheshwari, Jina Ok, Chau To, Sally Hodder, James M. Bardes, Daphne Dominique-Villanueva, Joy Juskowich, Rebecca Reece, Arif R Sarwari, Judd E. Shellito, Lucio Miele, Frank L. Greenway, John P. Kirwan, Clifford J. Rosen, Ivette F. Emery, Theresa Roelke, Susan E. Hoover, Lora Black, B Joel Tjarks, Vivian Fonseca, Shaveeta Gupta, Michele Longo, Mei Yang, Cecilia M. Shikuma, Dominic C. Chow, Louis MarGangcuangco, Mario Castro, Charles D. Bengtson, Theresa Howard, Leslie Spikes, Christopher Simmons, Sidney W. Whiteheart, Beth A. Garvy, Jeremy P. Wood, Gailen D. Marshall, Vishnu Garla, Joy Kuebler, Utsav Nandi, Andrew Vasey, David E. Warren, John D. Dickinson, Timothy M. VanWagoner, Amanda Bogie, Judith A. James, James Scott, Fatima I. Sukhera, Carlos A. Luciano Roman, Sigrid Perez Frontera, Jorge Santana Bagur, Jonathan D. Klein, Jerry A. Krishnan, Naoko Muramatsu, Bellur S. Prabhakar, Heather M. Prendergast, Terry L. Vanden Hoek, Janet Y. Lin, Dara R. Adams, Aileen Baker, Sunni Barbera, Sanjib Basu, Susan C Bleasdale, Andrew D. Boyd, Taylor Breiter, Irina A. Buhimschi, Michael D. Carrithers, Rashmika Chalamalla, David Chestek, Judith Α. Cook, Dawood Darbar, Raktima Dasgupta, Felicia Davis Blakley, Julie A. DeLisa, Kathleen R. Diviak, Meghan F. Donlon, Mark S. Dworkin, Angela M. Ellison, Clarie Flanigan, Michael B. Freedman, Lynn B. Gerald, Wayne H. Giles, Howard S. Gordon, Bayan Hammad, Sharon Hasek, Wendy Hasse, Martyna Hryniewicka, Sai D. Illendula, Nahed Ismail, Akash Jain, Kyle J. Jennette, Grace Kadubek, Denise A. Kent, Denise A. Kent, Keri S. Kim, Pavitra Kotini-Shah, Lucia Large, James P. Lash, Jun Lü, Abeer M. Mahamed, Sergey Malchenko, Miriam Martínez, Cammeo Mauntel‐Medici, Mark McCauley, Martha Menchaca, Robin Mermelstein, David J. Moreno, Liam Morrissy, Hugh Musick, Lourdes Norwick, Richard Novák, Marilyn Ortiz, Khushboo Patel, Nicolas L. Perez, Neil H. Pliskin, Sam Pope, Bharati Prasad, Barbara Predki, John G. Quigley, Ramaswamy Ramchandran, Ana Ramírez, Sarah Rappe, Jalees Rehman, Matthew Rowley, Gowrisree Rudraraju, Melissa Rutherfoord, Jennifer A. Sculley, Jerisha Smith-Mack, Jun Sun, Nancy Tartt, Laura Villanueva, Sara Warfield Kelly, Cemal Yazıcı, Marta Certa, Erica Chessier, Emily Everett, Elijah Kindred, Pastor C. Harris, Praveen Sudhindra, Lela Olds, Lisa Aponte‐Soto, Marina Del Rios, Maya Z. Diaz, Alejandra L. Ibanez, Cesar Rolon, Savannah Cranford, Daniel B. Brown, Jennifer Dixon, Lisa Gale, Savannah Hammerl, Kimberly Hartwig, Abhigna Madineni, Peyton Swearingen, Monica Hendrickson, Seth Noland, Tracy Terlinde, Brianna Hobbs, Sarah A. Stewart de Ramirez, Dawn Bolliger, Jerusha Boyineni, Praneeth Chebrolu, Hannah L. Curry, Sarah E. Donohue, Sherrie Edmonds, Sara W. Kelly, Phoebe Maholovich, Samer B. Sader, Tiffany Thompson, Hannah Welter, Brittany Woolley, John W. Hafner, Keith A. Hanson, Robert Hutton, Alexander W. Charney, Patricia Kovatch, Miriam Mérad, Girish N. Nadkarni, Juan P. Wisnivesky, Judith A. Aberg, Steven Ascolillo, Esther Assenso, Emilia Bagiella, Logan Bartram, Jacqueline Becker, Noam D. Beckmann, Ashley Bendl, Benjamin K. Chen, Alyssa Civil, K. Dhar, Lorraine Evo-Ortega, Daniel S. Fierer, Emily J. Gallagher, Sacha Gnjatic, Sabina Guliyeva, Lori Harvey-Ingram, Julia Herrera-Moreno, Matthew Hill, Carol R. Horowitz, Rachel Jackson, Din Kastrat, Anu Lala-Trindade, Jenny J. Lin, Nick Macaluso, Kathryn Marcon, Dara Meyer, Janice Morinigo, Benjamin H. Natelson, Maya Nussenzweig, Tiffani Padua, David Putrino, Nawreen Quazi, Michelle Ramos, Lynne Richardson, Scott J. Russo, Alan C. Seifert, Abdullah Serri, Jordan Walker, Michell Yee, Rachel Hess, Dongngan T. Truong, Lucinda Bateman, Bailee Aguirre, Natalya Alekhina, Kelly Auer, Tami L. Bair, Jackson Barlocker, Jill Bastman, Lindsay Bosh, Jeanette P. Brown, Nick Charron, Melissa Cortez, Jesse Cwik, Dagny K Donohue, Lorlie Evans, Julio C. Facelli, Isaac Ford, Dylan C. Freston, Chase Garrett, Adit A. Ginde, Ramkiran Gouripeddi, Amy Harjes, Dixie Harris, Jessica A. Hermansen, Katherine Herrera, Eliotte L. Hirshberg, David Huynh, Jace D. Johnny, James Juan, Lindsay Leither, Ashton M. Lindsay, Leah Ling, Jennifer E. V. Lloyd, Debbie M. Lovato, Yue Lü, Heather Maestas, Juliemar C. Medina, Aaron Mobley, Sarah Shizuko Morimoto, John Nguyen, Laura Pace, Tristan Planelles, Jenny M. Powell, Darija Runjaic-Ward, Mary Beth Scholand, Kevin Shah, Nasser Sharareh, Adam M. Spivak, Caitlyn Stringham, Joel D. Trinity, Matt Velinder, Lisa J. Weaver, Shyanne Zubal, Lucinda Bateman, Suzanne D. Vernon, Sara J. Deakyne Davies, Edward M. Gardner, Tanner W. Bryan, Kaitlin E. Buck, Tewodros Haile Gebremariam, Kellie L. Hawkins, Judy Oakes, Benjamin D. Horne, Kirk U. Knowlton, Scott C. Woller, Jeff Anderson, Stacey Knight, Heidi T. May, Gabriel Najarian, Kristine M. Erlandson, Ron J. Sokol, Marisa Brightman, Debra Davis, Elen Feuerriegel, Harrison Z. Fudge, Lohit Garg, Paige Graham, Janine Higgins, Brandon M. Johnson, Sarah E. Jolley, Tim Lockie, Sean McCandless, Joie Molden, Megan Owen, Chloe Pitch, Kayleigh M. Reid, Jane E.B. Reusch, Brook Thurman, Giang Huong Tran, Shelby C. West, Thomas Wodushek, Naomi P. Friedman, Katelyn R. Ludwig, Lauren A. Decker, Hengameh Raissy, Natalie L. Adolphi, David A. Archuleta, Steven B. Bradfute, Rebecca Brito, Jamie Elifritz, Noella D. Garcia-Soberanez, Frederick D. Gentry, Eve G. Gronert, Michelle Harkins, Noah I. Martinez, Lorenzo A. Montoya, Alisha N. Parada, Davin K. Quinn, Alfredo Ramos, Elyce B. Sheehan, Irena S. Treacher, Grace A. McComsey, David C. Kaelber, Cara Adams, Ornina Atieh, Jhony Baissary, Alexis Baloi, Emma Barnboym, Nicholas Boldt, Ann Conrad, Mary Consolo, Lynette Curtis, Brian D’Anza, Kathryn DiFrancesco, Ebenezer Eteshola, Michelle Gallagher, Paul Harris, Carla Hernandez, Morgan Hershey, Shirin Iqbal, Joshua Jacob, Olivia Kennedy, Danielle Labbato, Antonio Levert, Jennifer Levin, Joaquin Lim, Shahdi K. Malakooti, Christian Mouchati, Ann Pearman, Kimberly Pettinato, Amanda Rivera, Michael Rodgers, Theresa Rodgers, Arnab Roy, Sarah Scott, Niyati Sheth, Beth Smith, Viral Tejani, Megan Tribout, George A. Yendewa, David Zhang, Sokratis N. Zisis, Hulya Bukulmez, Kelly S. Gibson, Nora G. Singer, Mirna Ayache, Hailey Chesnick, Marissa Edminston, Larraine Gordesky, Carla Greenwood, Maricela Haghiac, Elizabeth S. Kaufman, Ketrin Lengu, Rebecca Lowenthal, Bridget Mackin, Judy Minium, Christine Oleson, Kris Russ, Cheryl Smith, Terry Stancin, Daniel Temple, Elisheva Weinberger, James R. Heath, Conor Brennan, Rick Edmark, Vanessa Gutiérrez, Jennifer Hadlock, Sarah Li, Andrew T. Magis, Connor McDonald, Kim M. Murray, Lee Rowen, Dan Yuan, Peter Chen, Antonina Caudill, Tananshi Chopra, Fatima Contreras, Lea Dahlke, Lasya Gudipudi, Susan Jackman, Matthew Modes, Nicole Muttera, Tanyalak Parimon, Nancy Salinas, Josie Tadeo, Sam Torbati, Katherine R. Tuttle, Radica Z. Alicic, Joni Baxter, Sarah Emerson, Susan Hood, Kelli Kuykendall, Shane White, L Wilcox, Jason D. Goldman, Heather A. Algren, James Del Alcazar, Alexandria M. Duven, Stephanie S. Godfrey, John Kaneko, Christina Kim, Paula Manner, Carly Mason, Rachel Poussier, Richard Satira, Julie A. Wallick, Helen Y. Chu, Megan Kemp, Jennifer K. Logue, Dylan McDonald, Callista Nackviseth, Helen Nguyen, Kino Watanabe, Thomas F. Patterson, Jennifer Sharpe Potter, Marzieh Salehi, Monica Verduzco‐Gutierrez, Ellen Kraig, Anoop M. Nambiar, Kumar Sharma, Reed Anderson, Azaneth Arellanes, Rose Ann Barajas, Geoffrey D. Clarke, Suneet P. Chauhan, Cheryl E. Farner, M Fischer, Mark P. Goldberg, Gabrielyd Hastings, Patricia Heard, Italia Herrera, Edgar Infante, Hillary Johnson, Johnnie Jones, Dean L. Kellogg, Lisa Longoria, Emeka Emmanuel Okafor, Jan E. Patterson, Alexis Pinones, William Reeves, Irma Scholler, Sudha Seshadri, Dimpy P. Shah, Pankil Shah, Bridgette Soileau, Pamela Solis, Carmen Stoebner, Michael B. Sullivan, Barbara S. Taylor, Robin Tragus, Joel Tsevat, Keren Hasbani, George R. Saade, Kavita Sharma, Claudia C. Paredes-Amaya, Stephanie Alvarado, Yvonne Maldonado, Upinder Singh, Paul J. Utz, Catherine A. Blish, Minjoung Go, Prasanna Jagannathan, Neera Ahuja, Andra L. Blomkalns, Hector Bonilla, Richard Brotherton, Kimberly Clinton, Vaidehi Dingankar, Linda N. Geng, Francois Haddad, Christopher Jamero, Kathryn Jee, Xiaolin Jia, Naresh Khurana, Andre Kumar, Mitchell G. Miglis, Ellen O’Conor, Kelly Olszewski, Divya Pathak, Orlando Quintero, Corey Saperia, Jake Scott, Alfredo E. Urdaneta, Mary Rithu Varkey, Janko Ž. Nikolich, Sairam Parthasarathy, Kacey C. Ernst, Denise Rodríguez Esquivel, David T. Harris, Stefanie Harris, Michael Hernandez, Harvey Hsu, Maria Karnafel, Kenneth S. Knox, Alison Koleski, Bonnie LaFleur, Brenda Lambert, Sicily LaRue, Karen Lutrick, Nirav Merchant, Christopher Morton, Jarrod Mosier, Toluwanimi Olorunnisola, Jeanette Peralta, William . Pilling, Kristen Pogreba-Brown, Franz Rischard, Lee T. Ryan, Terry Smith, M. L. Snyder, Vignesh Subbian, Kyle Suhr, D.T. Velarde, Eric M. Reiman, Joyce Lee‐Iannotti, Lynn Autry, Sabine Borwege, Jacquelynn Copeland, Marjorie DiLise-Russo, Susan Fadden, Isaias Gomez, Garrett Grischo, William Hartley, Leah Hillier, Hira Ismail, Stephanie Iusim, Michelle A. James, Mrinalini Kala, Daniel Kim, Ganesh Murthy, Samuel Unzek, Sheila Vadovicky, Sharry Veres, Christian Bime, Lillian Hansen, Trina Hughes, David Lieberman, Francisco Soto, Cathleen Wilson, Steven G. Deeks, J. Daniel Kelly, Jeffrey N. Martin, Michael J. Peluso, Grace Anderson, Khamal Anglin, Urania Argueta, Kofi Asare, Melissa Buitrago, Celina Chang Song, Alexus Clark, Emily Conway, Nicole Del Castillo, Monika Deswal, Matthew S. Durstenfeld, Elnaz Eilkhani, Avery Eun, Emily A. Fehrman, Tony Figueroa, Diana Flores, Halle Grebe, Timothy J. Henrich, Rebecca Hoh, Priscilla Hsue, Beatrice Huang, Rania Ibrahim, Marian Kerbleski, Raushun Kirtikar, Megan T. Lew, James Lombardo, Mónica López‐Peña, Michael Luna, Carina Marquez, Sadie E. Munter, Lynn Ngo, Jesus Pineda-Ramirez, Kim F. Rhoads, Antonio Rodríguez, Justin Romero, Dylan Ryder, Matthew So, Ma Somsouk, Viva Tai, Brandon Tran, J. Uy, Daisy Valdivieso, Deepshika Verma, Meghann Williams, Andhy Zamora, Sonseeahray Adams, Teresa Akintonwa, Leyna Aragon, Bryan Bander, Karyn Bishof, Frank Blancero, G. Daniel Brooks, Etienne Carignan, Megan Carmilani, Leah Castro-Baucom, Marta Cerda, Krista Coombs, Debra Copeland, Claudia Corchado, Hannah Davis, Felicia Davis Blakley, Marissa Diggs, Belinda Edwards, Heather E. Brown, Umar Favors, Whitney Fields, Liza Fisher, Megan Fitzgerald, Margot Gage Witvliet, Roberto García, Tyler Gustafson, Nick Güthe, Yvonka Hall, Verna Holmes, Mady Hornig, Maxwell Hornig, Wendy Jefferson, Christina Kim, Nancy Kochis, kevin kondo, Julie A. Lam, Fadwa Lawrence, Lydia Lerma, Rebecca Letts, Juan Lewis, Jacqui Lindsay, Silcia Lopez, Heather Marti, Thomas F. Martínez, Christine Maughan, Lisa McCorkell, Rebecca McGrath, Thomas T. Minor, Charita Moore, Kian Nguyen, Lauren Nichols, Lisa O’Brien, Holly Olson, Aimee Peddie, Elizabeth Phillips Lorenzo, Lisa Prentiss, Nadia Raytselis, Lidia Regino, Marjorie Roberts, Nitza Rochez, Megan Rockwell, Jacqueline Rutter, Nitza Rochez, Elle Seibert, Anisha Sekar, Chimere Smith, Lauren E. Stiles, Brittany Taylor, Emily Taylor, Julie M. Thompson, Stephen K. Trapp, Stephen Valdiva, Hyatt Vincent, Ann Wallace, R. Wilensky, Melissa Williams, Neely Williams, Kay W. Dawson, Andrew Wylam, Mike Zissis · 发表于：Annals of Internal Medicine · 年份：2024 · DOI：10.7326/m24-0737 · 被引用次数：49 · 研究领域：Long-Term Effects of COVID-19、Pharmacological Receptor Mechanisms and Effects、Intensive Care Unit Cognitive Disorders

BACKGROUND: There are currently no validated clinical biomarkers of postacute sequelae of SARS-CoV-2 infection (PASC). OBJECTIVE: To investigate clinical laboratory markers of SARS-CoV-2 and PASC. DESIGN: Propensity score-weighted linear regression models were fitted to evaluate differences in mean laboratory measures by prior infection and PASC index (≥12 vs. 0). (ClinicalTrials.gov: NCT05172024). SETTING: 83 enrolling sites. PARTICIPANTS: RECOVER-Adult cohort participants with or without SARS-CoV-2 infection with a study visit and laboratory measures 6 months after the index date (or at enrollment if >6 months after the index date). Participants were excluded if the 6-month visit occurred within 30 days of reinfection. MEASUREMENTS: Participants completed questionnaires and standard clinical laboratory tests. RESULTS: levels was attenuated after participants with preexisting diabetes were excluded. Among participants with prior infection, no meaningful differences in mean laboratory values were found between those with a PASC index of 12 or higher and those with a PASC index of zero. LIMITATION: Whether differences in laboratory markers represent consequences of or risk factors for SARS-CoV-2 infection could not be determined. CONCLUSION: Overall, no evidence was found that any of the 25 routine clinical laboratory values assessed in this study could serve as a clinically useful biomarker of PASC. PRIMARY FUNDING SOURCE: National Institutes of Health.