The burden and contemporary epidemiology of sepsis in children

作者：R. Scott Watson, Enitan D. Carrol, Michael J. Carter, Niranjan Kissoon, Suchitra Ranjit, Luregn J. Schlapbach · 发表于：The Lancet Child & Adolescent Health · 年份：2024 · DOI：10.1016/s2352-4642(24)00140-8 · 被引用次数：108 · 研究领域：Sepsis Diagnosis and Treatment、Respiratory Support and Mechanisms、Renal function and acid-base balance

Sepsis is a dysregulated host response to infection that leads to life-threatening organ dysfunction. Half of the 50 million people affected by sepsis globally every year are neonates and children younger than 19 years. This burden on the paediatric population translates into a disproportionate impact on global child health in terms of years of life lost, morbidity, and lost opportunities for children to reach their developmental potential. This Series on paediatric sepsis presents the current state of diagnosis and treatment of sepsis in children, and maps the challenges in alleviating the burden on children, their families, and society. Drawing on diverse experience and multidisciplinary expertise, we offer a roadmap to improving outcomes for children with sepsis. This first paper of the Series is a narrative review of the burden of paediatric sepsis from low-income to high-income settings. Advances towards improved operationalisation of paediatric sepsis across all age groups have facilitated more standardised assessment of the Global Burden of Disease estimates of the impact of sepsis on child health, and these estimates are expected to gain further precision with the roll out of the new Phoenix criteria for sepsis. Sepsis remains one of the leading causes of childhood morbidity and mortality, with immense direct and indirect societal costs. Although substantial regional differences persist in relation to incidence, microbiological epidemiology, and outcomes, these cannot...