A Robust In Vitro Anti‐tuberculosis, Antimicrobial, and Anti‐inflammatory Activities Based on Azomethine Chelates Incorporating Co(II), Ni (II), Cu(II), and Zn(II) Ions: Synthesis, Characterization, and Investigation of the Aspects of Docking Interaction

作者：Manju Rani, Jai Devi, Jai Kumar, Dhananjay Sharma · 发表于：Applied Organometallic Chemistry · 年份：2024 · DOI：10.1002/aoc.7664 · 被引用次数：10 · 研究领域：Synthesis and Characterization of Heterocyclic Compounds、Metal complexes synthesis and properties、Click Chemistry and Applications

ABSTRACT In recent times, there has been a growing exploration of transition metal complexes as potential solutions for significant health challenges, including tuberculosis, microbes infection, and inflammation. Therefore, in our ongoing effort to identify biologically effective agents, Co(II), Ni(II), Cu(II), and Zn(II) metal complexes of H 2 L 1 –H 2 L 2 hydrazone ligands were synthesized. The structural features of synthesized compounds were recognized by employing several techniques such as FT‐IR, 1 H NMR, 13 C NMR, powder x‐ray diffraction (XRD), UV‐Vis, ESR, TG‐DTA, mass spectrometry, and molar conductance measurements. The bonding of ligands via O phenolic , O enolic , and N azomethine donor atoms and the attachment of the three water molecules with metal ion to form the octahedral structure of complexes were corroborated by different spectroscopic techniques. The anti‐tuberculosis, antimicrobial, and anti‐inflammatory activities of the synthesized compounds were assessed using the microplate alamar blue assay, serial dilution, and bovine serum albumin (BSA) methods, respectively, and highlighted the more potency of the complexes than ligands. The synthesized Cu(II) (9 ) and Zn(II) ( 10 ) metal complexes exhibited excellent ability to inhibit the growth of H 37 R v strain of Mycobacterium tuberculosis in comparison to standard drug streptomycin. The Cu(II) ( 6 and 9 ) and Zn(II) ( 10 ) complexes showed superb ability as antimicrobial agents, whereas Cu(II) ( 5 ) and Z...