Central nervous system prophylaxis in large B‐cell lymphoma: A British Society for Haematology Good Practice Paper

作者：Matthew R. Wilson, Kate Cwynarski, Toby A. Eyre, Jeffery Smith, Sridhar Chaganti, Christopher P. Fox, Pam McKay · 发表于：British Journal of Haematology · 年份：2024 · DOI：10.1111/bjh.19686 · 被引用次数：10 · 研究领域：CNS Lymphoma Diagnosis and Treatment、Lymphoma Diagnosis and Treatment、Chronic Lymphocytic Leukemia Research

This Good Practice Paper provides recommendations for the baseline investigation, risk stratification and use of prophylactic interventions for patients with large B-cell lymphoma at risk of central nervous system relapse. Recent evidence which has questioned the role of high-dose methotrexate in this clinical scenario is discussed in detail.