Identification of PANoptosis-relevant subgroups and predicting signature to evaluate the prognosis and immune landscape of patients with biliary tract cancer

作者：Dongming Liu, Wenshuai Chen, Zhiqiang Han, Yu Wang, Wei Liu, Aomei Ling, Qiang Wu, Huikai Li, Hua Guo · 发表于：Hepatology International · 年份：2024 · DOI：10.1007/s12072-024-10718-x · 被引用次数：7 · 研究领域：Cholangiocarcinoma and Gallbladder Cancer Studies、Ferroptosis and cancer prognosis、Inflammasome and immune disorders

BACKGROUND: This study conducted molecular subtyping of biliary tract cancer patients based on 19 PANoptosis-related gene signatures. METHODS: Through consensus clustering, patients were categorized into two subtypes, A and B. By integrating multi-omics data and clinical information from different cohorts, we elucidated the association between different subtypes of biliary tract cancer and patient prognosis, which correlated with the immune infiltration characteristics of patients. RESULTS: LASSO regression analysis was performed on the 19 gene signatures, and we constructed and validated a 9-gene risk score prognostic model that accurately predicts the overall survival rate of different biliary tract cancer patients. Additionally, we developed a predictive nomogram demonstrating the clinical utility and robustness of our model. Further analysis of the risk score-based immune landscape highlighted potential associations with immune cell infiltration, chemotherapy, and immune therapy response. CONCLUSION: Our study provides valuable insights into personalized treatment strategies for biliary tract cancer, which are crucial for improving patient prognosis and guiding treatment decisions in clinical practice.